Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR011546

Description

IPR011546 is a Peptidase M41, FtsH extracellular.

<p>Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. The known metal ligands are His, Glu, Asp or Lys. At least one other residue is required for catalysis, which may play an electrophillic role. Many metalloproteases contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site [[cite:PUB00003579]]. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [[cite:PUB00003579]].</p> <p>This domain is found in the FtsH family of proteins that include FtsH a membrane-bound ATP-dependent protease universally conserved in prokaryotes [[cite:PUB00012629]]. The FtsH peptidases, which belong to MEROPS peptidase family M41 (clan MA(E)), efficiently degrade proteins that have a low thermodynamic stability - e.g. they lack robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni (Leuconostoc oenos) FtsH is involved in protection against environmental stress [[cite:PUB00012628]], and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded. The precise function of this N-terminal region is unclear.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Associated Lotus transcripts 10

Transcript Name Description Predicted domains Domain count
AAA-metalloprotease FtsH [Pisum sativum] gi|15021761|gb|AAK77908.1|AF397903_1 25
PREDICTED: ATP-dependent zinc metalloprotease FTSH 10, mitochondrial-like isoform X1 [Cicer arietinum] gi|502148467|ref|XP_004507174.1| 28
ATP-dependent zinc metalloprotease FtsH; TAIR: AT3G02450.1 cell division protein ftsH; Swiss-Prot: sp|Q9M895|FTSI3_ARATH Probable inactive ATP-dependent zinc metalloprotease FTSHI 3, chloroplastic; TrEMBL-Plants: tr|I1N6J7|I1N6J7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0059700 20
ATP-dependent zinc metalloprotease FTSH protein; TAIR: AT1G07510.1 FTSH protease 10; Swiss-Prot: sp|Q8VZI8|FTSHA_ARATH ATP-dependent zinc metalloprotease FTSH 10, mitochondrial; TrEMBL-Plants: tr|A0A1J7GZI6|A0A1J7GZI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0375900 31
ATP-dependent zinc metalloprotease FTSH protein; TAIR: AT1G07510.1 FTSH protease 10; Swiss-Prot: sp|Q8VZI8|FTSHA_ARATH ATP-dependent zinc metalloprotease FTSH 10, mitochondrial; TrEMBL-Plants: tr|A0A1J7GZI6|A0A1J7GZI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0375900 31
ATP-dependent zinc metalloprotease FTSH protein; TAIR: AT1G07510.1 FTSH protease 10; Swiss-Prot: sp|Q8VZI8|FTSHA_ARATH ATP-dependent zinc metalloprotease FTSH 10, mitochondrial; TrEMBL-Plants: tr|A0A1J7GZI6|A0A1J7GZI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0375900 31
ATP-dependent zinc metalloprotease FTSH protein; TAIR: AT1G07510.1 FTSH protease 10; Swiss-Prot: sp|Q8VZI8|FTSHA_ARATH ATP-dependent zinc metalloprotease FTSH 10, mitochondrial; TrEMBL-Plants: tr|Q94ES0|Q94ES0_PEA AAA-metalloprotease FtsH; Found in the gene: LotjaGi2g1v0376100 30
ATP-dependent zinc metalloprotease FTSH protein; TAIR: AT1G07510.1 FTSH protease 10; Swiss-Prot: sp|Q8VZI8|FTSHA_ARATH ATP-dependent zinc metalloprotease FTSH 10, mitochondrial; TrEMBL-Plants: tr|A0A1J7GZI6|A0A1J7GZI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0376100 32
ATP-dependent zinc metalloprotease FTSH protein; TAIR: AT1G07510.1 FTSH protease 10; Swiss-Prot: sp|Q8VZI8|FTSHA_ARATH ATP-dependent zinc metalloprotease FTSH 10, mitochondrial; TrEMBL-Plants: tr|A0A1J7GZI6|A0A1J7GZI6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0376100 32
ATP-dependent zinc metalloprotease FTSH protein; TAIR: AT5G58870.1 FTSH protease 9; Swiss-Prot: sp|Q9FIM2|FTSH9_ARATH ATP-dependent zinc metalloprotease FTSH 9, chloroplastic; TrEMBL-Plants: tr|A0A068FWX3|A0A068FWX3_CICAR Metalloprotease; Found in the gene: LotjaGi6g1v0132900 29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 10.00