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IPR011629 is a Zinc chaperone CobW-like, C-terminal.
<p>CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis [[cite:PUB00015657], [cite:PUB00078797]]. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids.</p> <p>This entry represents the C-terminal domain found in CobW, as well as in P47K ([swissprot:P31521]), a Pseudomonas chlororaphis protein needed for nitrile hydratase expression [[cite:PUB00035321]].</p> <p>Cobalamin (vitamin B12) is a structurally complex cofactor, consisting of a modified tetrapyrrole with a centrally chelated cobalt. Cobalamin is usually found in one of two biologically active forms: methylcobalamin and adocobalamin. Most prokaryotes, as well as animals, have cobalamin-dependent enzymes, whereas plants and fungi do not appear to use it. In bacteria and archaea, these include methionine synthase, ribonucleotide reductase, glutamate and methylmalonyl-CoA mutases, ethanolamine ammonia lyase, and diol dehydratase [[cite:PUB00015657]]. In mammals, cobalamin is obtained through the diet, and is required for methionine synthase and methylmalonyl-CoA mutase [[cite:PUB00035308]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: COBW domain-containing protein 2-like [Glycine max] gi|356559093|ref|XP_003547836.1| | 13 | ||
| – | COBW domain-containing protein [Medicago truncatula] gi|357487507|ref|XP_003614041.1| | 12 | ||
| – | COBW domain-containing protein [Medicago truncatula] gi|357487507|ref|XP_003614041.1| | 13 | ||
| – | PREDICTED: COBW domain-containing protein 1-like [Cicer arietinum] gi|502121422|ref|XP_004497313.1| | 12 | ||
| – | CobW-domain-containing protein; TAIR: AT1G26520.1 Cobalamin biosynthesis CobW-like protein; Swiss-Prot: sp|Q99MB4|CBWD1_RAT COBW domain-containing protein 1; TrEMBL-Plants: tr|I3S5R3|I3S5R3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0296000 | 15 | ||
| – | CobW-domain-containing protein; TAIR: AT1G80480.1 plastid transcriptionally active 17; Swiss-Prot: sp|Q8VEH6|CBWD1_MOUSE COBW domain-containing protein 1; TrEMBL-Plants: tr|A0A0L9TNH2|A0A0L9TNH2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0146300 | 15 | ||
| – | CobW-domain-containing protein; TAIR: AT1G80480.1 plastid transcriptionally active 17; Swiss-Prot: sp|P24203|YJIA_ECOLI Uncharacterized GTP-binding protein YjiA; TrEMBL-Plants: tr|A0A072U3B1|A0A072U3B1_MEDTR Prli-interacting factor L-like protein; Found in the gene: LotjaGi4g1v0146300 | 9 | ||
| – | CobW-domain-containing protein; TAIR: AT1G80480.1 plastid transcriptionally active 17; Swiss-Prot: sp|Q8IUF1|CBWD2_HUMAN COBW domain-containing protein 2; TrEMBL-Plants: tr|A0A0R0I7G4|A0A0R0I7G4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0358000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |