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IPR003495 is a CobW/HypB/UreG, nucleotide-binding domain.
<p>This domain is found in HypB, a hydrogenase expression/formation protein, and urease accessory protein UreG. Both these proteins contain a P-loop nucleotide binding motif [[cite:PUB00002310], [cite:PUB00002230]]. HypB has GTPase activity and is a guanine nucleotide binding protein [[cite:PUB00002230]]. UreG is a GTPase in charge of nucleotide hydrolysis required for activation of the urease enzyme [[cite:PUB00078798]]. Both GTPases are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression [[cite:PUB00003878]]. UreG is required for functional incorporation of the urease nickel metallocentre [[cite:PUB00002187]]. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins [[cite:PUB00003878]].</p> <p>Other proteins containing this domain include P47K ([swissprot:P31521]), a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, CobW ([swissprot:P29937]), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans [[cite:PUB00008140]], and YjiA [[cite:PUB00029084]]. Both CobW and YjiA are members of the metal homeostasis-associated COG0523 family of GTPases [[cite:PUB00078797]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: COBW domain-containing protein 2-like [Glycine max] gi|356559093|ref|XP_003547836.1| | 13 | ||
| – | COBW domain-containing protein [Medicago truncatula] gi|357487507|ref|XP_003614041.1| | 12 | ||
| – | PREDICTED: urease accessory protein UreG-like [Cicer arietinum] gi|502141882|ref|XP_004504685.1| | 11 | ||
| – | Ni-binding urease accessory protein UreG [Glycine max] gi|351721504|ref|NP_001238235.1| | 8 | ||
| – | COBW domain-containing protein [Medicago truncatula] gi|357487507|ref|XP_003614041.1| | 13 | ||
| – | PREDICTED: COBW domain-containing protein 1-like [Cicer arietinum] gi|502121422|ref|XP_004497313.1| | 12 | ||
| – | CobW-domain-containing protein; TAIR: AT1G26520.1 Cobalamin biosynthesis CobW-like protein; Swiss-Prot: sp|Q99MB4|CBWD1_RAT COBW domain-containing protein 1; TrEMBL-Plants: tr|I3S5R3|I3S5R3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0296000 | 15 | ||
| – | Urease accessory protein UreG; TAIR: AT2G34470.2 urease accessory protein G; Swiss-Prot: sp|O64700|UREG_ARATH Urease accessory protein G; TrEMBL-Plants: tr|I3SUK1|I3SUK1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0023100 | 11 | ||
| – | Urease accessory protein UreG; TAIR: AT2G34470.1 urease accessory protein G; Swiss-Prot: sp|O64700|UREG_ARATH Urease accessory protein G; TrEMBL-Plants: tr|I3SUK1|I3SUK1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0023100 | 11 | ||
| – | Urease accessory protein UreG; TAIR: AT2G34470.1 urease accessory protein G; Swiss-Prot: sp|O64700|UREG_ARATH Urease accessory protein G; TrEMBL-Plants: tr|I3SUK1|I3SUK1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0023100 | 11 | ||
| – | Urease accessory protein ureG; TAIR: AT2G34470.2 urease accessory protein G; Swiss-Prot: sp|O64700|UREG_ARATH Urease accessory protein G; TrEMBL-Plants: tr|I3SUK1|I3SUK1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0023100 | 11 | ||
| – | CobW-domain-containing protein; TAIR: AT1G80480.1 plastid transcriptionally active 17; Swiss-Prot: sp|Q8VEH6|CBWD1_MOUSE COBW domain-containing protein 1; TrEMBL-Plants: tr|A0A0L9TNH2|A0A0L9TNH2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0146300 | 15 | ||
| – | CobW-domain-containing protein; TAIR: AT1G80480.1 plastid transcriptionally active 17; Swiss-Prot: sp|Q8IUF1|CBWD2_HUMAN COBW domain-containing protein 2; TrEMBL-Plants: tr|A0A0R0I7G4|A0A0R0I7G4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0358000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |