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IPR011949 is a HAD-superfamily hydrolase, subfamily IA, REG-2-like.
<p>This family of proteins includes uncharacterised sequences from eukaryotes, cyanobacteria and Leptospira as well as the DREG-2 protein from Drosophila melanogaster (Fruit fly) which has been identified as a rhythmically (diurnally) regulated gene [[cite:PUB00015520]]. This family is a member of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The superfamily is defined by the presence of three short catalytic motifs [[cite:PUB00003337]]. The subfamilies are defined [[cite:PUB00009540]] based on the location and the observed or predicted fold of a so-called, capping domain, [[cite:PUB00009540]], or the absence of such a domain. This family is a member of subfamily 1A in which the cap domain consists of a predicted α helical bundle found in between the first and second catalytic motifs. A distinctive feature of this family is a conserved tandem pair of tryptophan residues in the cap domain. The most divergent sequences included within the scope of this entry are from plants and have "FW" at this position instead. Most likely, these sequences, like the vast majority of HAD sequences, represent phosphatase enzymes.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: haloacid dehalogenase-like hydrolase domain-containing protein 3-like [Cicer arietinum] gi|502108258|ref|XP_004493428.1| | 14 | ||
| – | Haloacid dehalogenase-like hydrolase domain-containing protein [Medicago truncatula] gi|357486883|ref|XP_003613729.1| | 12 | ||
| – | Haloacid dehalogenase-like hydrolase domain-containing protein [Medicago truncatula] gi|357449159|ref|XP_003594856.1| | 12 | ||
| – | Haloacid dehalogenase-like hydrolase domain-containing protein [Medicago truncatula] gi|357449159|ref|XP_003594856.1| | 12 | ||
| – | Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT2G41250.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q5M969|NANP_RAT N-acylneuraminate-9-phosphatase; TrEMBL-Plants: tr|I3T9E2|I3T9E2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0666900 | 19 | ||
| – | Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT1G14310.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q9CYW4|HDHD3_MOUSE Haloacid dehalogenase-like hydrolase domain-containing protein 3; TrEMBL-Plants: tr|I1J5P8|I1J5P8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0304800 | 17 | ||
| – | Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT5G44730.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q5E9D6|HDHD3_BOVIN Haloacid dehalogenase-like hydrolase domain-containing protein 3; TrEMBL-Plants: tr|I3TAF4|I3TAF4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0244600 | 14 | ||
| – | Haloacid dehalogenase-like hydrolase domain-containing protein 3; TAIR: AT5G44730.1 Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; Swiss-Prot: sp|Q5E9D6|HDHD3_BOVIN Haloacid dehalogenase-like hydrolase domain-containing protein 3; TrEMBL-Plants: tr|I3TAF4|I3TAF4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0244600 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16415 | CDD | 1 | 12.50 |