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IPR013178 is a Histone acetyltransferase Rtt109/CBP.
<p>Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal RTT109 protein, which is required for H3K56 acetylation [[cite:PUB00042670]]. In Schizosaccharomyces pombe (Fission yeast) loss of RTT109 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin [[cite:PUB00045009]]. RTT109 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast [[cite:PUB00045009]]. This family also includes p300/CBP acetyltransferase, which has different catalytic properties and cofactor regulation to RTT109 [[cite:PUB00051225]]. CREB-binding protein (CBP) is a transcriptional co-activator that acetylates both histones and non-histone proteins [[cite:PUB00074833], [cite:PUB00074834], [cite:PUB00074835]]. CBP binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes [[cite:PUB00053723], [cite:PUB00053724]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. | ||
| Biological process | Histone acetylation | The modification of a histone by the addition of an acetyl group. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Histone acetyltransferase [Medicago truncatula] gi|357466361|ref|XP_003603465.1| | 15 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: histone acetyltransferase HAC1-like [Cicer arietinum] gi|502089455|ref|XP_004488916.1| | 28 | ||
| – | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
| – | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
| – | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
| – | Histone acetyltransferase; TAIR: AT1G16710.4 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9C5X9|HAC1_ARATH Histone acetyltransferase HAC1; TrEMBL-Plants: tr|K7KYS1|K7KYS1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
| – | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
| – | Histone acetyltransferase; TAIR: AT1G16710.9 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|A0A151RA54|A0A151RA54_CAJCA Histone acetyltransferase HAC12; Found in the gene: LotjaGi5g1v0201900_LC | 7 | ||
| – | Histone acetyltransferase; TAIR: AT1G79000.2 histone acetyltransferase of the CBP family 1; Swiss-Prot: sp|Q9C5X9|HAC1_ARATH Histone acetyltransferase HAC1; TrEMBL-Plants: tr|G7J5R6|G7J5R6_MEDTR Histone acetylation protein; Found in the gene: LotjaGi5g1v0202100 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |