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IPR035898 is a TAZ domain superfamily.
<p>TAZ (Transcription Adaptor putative Zinc finger) domains are zinc-containing domains found in the homologous transcriptional co-activators CREB-binding protein (CBP) and the P300. CBP and P300 are histone acetyltransferases ([ec:2.3.1.48]) that catalyse the reversible acetylation of all four histones in nucleosomes, acting to regulate transcription via chromatin remodelling. These large nuclear proteins interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis [[cite:PUB00005449]]. Both CBP and P300 have two copies of the TAZ domain, one in the N-terminal region, the other in the C-terminal region. The TAZ1 domain of CBP and P300 forms a complex with CITED2 (CBP/P300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration [[cite:PUB00029716]]. Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators [[cite:PUB00026905]].</p> <p>Proteins containing this domain also include a group of land-plant specific proteins, know as the BTB/POZ and TAZ domain-containing (BT) protein. The reports of their interaction with CUL3 are contradictory. They are multifunctional scaffold proteins essential for male and female gametophyte development [[cite:PUB00082643]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | BTB/POZ and TAZ domain protein; TAIR: AT5G67480.1 BTB and TAZ domain protein 4; Swiss-Prot: sp|Q9FJX5|BT4_ARATH BTB/POZ and TAZ domain-containing protein 4; TrEMBL-Plants: tr|I3TAA7|I3TAA7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0408600 | 20 | ||
– | BTB/POZ and TAZ domain protein; TAIR: AT5G67480.1 BTB and TAZ domain protein 4; Swiss-Prot: sp|Q9FJX5|BT4_ARATH BTB/POZ and TAZ domain-containing protein 4; TrEMBL-Plants: tr|I3TAA7|I3TAA7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0408600 | 20 | ||
– | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
– | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
– | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
– | Histone acetyltransferase; TAIR: AT1G16710.4 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9C5X9|HAC1_ARATH Histone acetyltransferase HAC1; TrEMBL-Plants: tr|K7KYS1|K7KYS1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
– | Histone acetyltransferase; TAIR: AT1G16710.10 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|I1KG14|I1KG14_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0338000 | 32 | ||
– | BTB/POZ and TAZ domain protein; TAIR: AT3G48360.1 BTB and TAZ domain protein 2; Swiss-Prot: sp|Q94BN0|BT2_ARATH BTB/POZ and TAZ domain-containing protein 2; TrEMBL-Plants: tr|D2KTV8|D2KTV8_LOTJA BTB/POZ domain-containing protein; Found in the gene: LotjaGi4g1v0225900 | 18 | ||
– | Histone acetyltransferase; TAIR: AT1G79000.2 histone acetyltransferase of the CBP family 1; Swiss-Prot: sp|Q9C5X9|HAC1_ARATH Histone acetyltransferase HAC1; TrEMBL-Plants: tr|G7J5R6|G7J5R6_MEDTR Histone acetylation protein; Found in the gene: LotjaGi5g1v0202100 | 27 | ||
– | Histone acetyltransferase; TAIR: AT1G16710.1 histone acetyltransferase of the CBP family 12; Swiss-Prot: sp|Q9FWQ5|HAC12_ARATH Histone acetyltransferase HAC12; TrEMBL-Plants: tr|G7JBQ0|G7JBQ0_MEDTR Histone acetylation protein; Found in the gene: LotjaGi5g1v0202300_LC | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 10.00 |