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IPR014306 is a Hydroxyisourate hydrolase.
<p>Members of this family, hydroxyisourate hydrolase, represent a distinct clade of transthyretin-related proteins. Bacterial members typically are encoded next to ureidoglycolate hydrolase and often near either xanthine dehydrogenase or xanthine/uracil permease genes and have been demonstrated to have hydroxyisourate hydrolase activity [[cite:PUB00034597]]. In eukaryotes, a clade separate from the transthyretins (a family of thyroid-hormone binding proteins) has also been shown to have HIU hydrolase activity in urate catabolizing organisms [[cite:PUB00043032]]. Transthyretin, then, would appear to be the recently diverged paralog of the more ancient HIUH family.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Purine nucleobase metabolic process | The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. | ||
| Molecular function | Hydroxyisourate hydrolase activity | Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: uric acid degradation bifunctional protein TTL-like isoform X2 [Cicer arietinum] gi|502155814|ref|XP_004510201.1| | 19 | ||
| – | PREDICTED: uric acid degradation bifunctional protein TTL-like isoform X1 [Cicer arietinum] gi|502155812|ref|XP_004510200.1| | 19 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|I1MM35|I1MM35_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 22 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|I1MM36|I1MM36_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 21 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|A0A151QU94|A0A151QU94_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 26 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|A0A151QU94|A0A151QU94_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05822 | CDD | 1 | 16.67 |