Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR023416 is a Transthyretin/hydroxyisourate hydrolase domain.
<p>This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU [[cite:PUB00034597], [cite:PUB00042841]]. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage [[cite:PUB00041243], [cite:PUB00002809]]. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.</p> <p>Transthyretin (formerly prealbumin) is one of 3 thyroid hormone-binding proteins found in the blood of vertebrates [[cite:PUB00001401]]. It is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine (T4) [[cite:PUB00001752], [cite:PUB00071851], [cite:PUB00101389]]. It differs from the other 2 hormone-binding proteins (T4-binding globulin and albumin) in 3 distinct ways: (1) the gene is expressed at a high rate in the brain choroid plexus; (2) it is enriched in cerebrospinal fluid; and (3) no genetically caused absence has been observed, suggesting an essential role in brain function, distinct from that played in the bloodstream [[cite:PUB00001401]]. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain [[cite:PUB00001401]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: uric acid degradation bifunctional protein TTL-like isoform X2 [Cicer arietinum] gi|502155814|ref|XP_004510201.1| | 19 | ||
| – | PREDICTED: uric acid degradation bifunctional protein TTL-like isoform X1 [Cicer arietinum] gi|502155812|ref|XP_004510200.1| | 19 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|I1MM35|I1MM35_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 22 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|I1MM36|I1MM36_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 21 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|A0A151QU94|A0A151QU94_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 26 | ||
| – | Transthyretin-like S-allantoin synthase protein; TAIR: AT5G58220.1 transthyretin-like protein; Swiss-Prot: sp|Q9LVM5|TTHL_ARATH Uric acid degradation bifunctional protein TTL; TrEMBL-Plants: tr|A0A151QU94|A0A151QU94_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0260800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05822 | CDD | 1 | 16.67 |