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IPR014732 is a Orotidine 5'-phosphate decarboxylase.
<p>Orotidine 5'-phosphate decarboxylase (OMPdecase) ([ec:4.1.1.23]) [[cite:PUB00003724], [cite:PUB00002768]] catalyses the last step in the <i>de novo</i> biosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional proteins.</p> <p>Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.</p> <p>OMPdecases adopt classical TIM-barrel fold with an active site located at one side of the barrel [[cite:PUB00024159], [cite:PUB00024322]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Orotidine-5'-phosphate decarboxylase activity | Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. | ||
| Biological process | 'de novo' UMP biosynthetic process | The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: uridine 5'-monophosphate synthase-like [Glycine max] gi|356548887|ref|XP_003542830.1| | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06223 | CDD | 1 | 16.67 |