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IPR023031 is a Orotate phosphoribosyltransferase.
<p>Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. In the pyrimidine synthesis pathway, OPRT catalyses the reversible phosphoribosyl transfer from 5'-phospho-alpha-D-ribose 1'-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5'-monophosphate (OMP) [[cite:PUB00060925]]. The structures and properties of the OPRTases from different species have been described in several publications [[cite:PUB00060929], [cite:PUB00060930], [cite:PUB00060931], [cite:PUB00060932]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Orotate phosphoribosyltransferase activity | Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. | ||
| Biological process | Pyrimidine nucleotide biosynthetic process | The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: uridine 5'-monophosphate synthase-like [Glycine max] gi|356548887|ref|XP_003542830.1| | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200 | 24 | ||
| – | Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06223 | CDD | 1 | 16.67 |