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IPR001754

Source: InterPro

Description

IPR001754 is a Orotidine 5'-phosphate decarboxylase domain.

<p>Orotidine 5'-phosphate decarboxylase (OMPdecase) [[cite:PUB00003724], [cite:PUB00002768]] catalyses the last step in the<i>de novo</i>biosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein.</p> <p>Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.</p> <p>This entry also includes enzymes such as 3-hexulose-6-phosphate synthase [ec:4.1.2.43] and 3-keto-L-gulonate-6-phosphate decarboxylase [ec:4.1.1.85].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004590
Molecular function Orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP.
Subterm of
GO:0006207
Biological process 'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
Subterm of

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
Lj0g3v0062759.1
– PREDICTED: uridine 5'-monophosphate synthase-like [Glycine max] gi|356548887|ref|XP_003542830.1|
Domains
24
LotjaGi3g1v0111900.1
– Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900
Domains
24
LotjaGi3g1v0111900.2
– Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900
Domains
24
LotjaGi3g1v0111900.3
– Orotidine 5'-phosphate decarboxylase; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42942|UMPS_TOBAC Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900
Domains
10
LotjaGi3g1v0111900.4
– Orotidine 5'-phosphate decarboxylase; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42942|UMPS_TOBAC Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|G7IYW1|G7IYW1_MEDTR Uridine 5-monophosphate synthase-like protein; Found in the gene: LotjaGi3g1v0111900
Domains
10
LotjaGi3g1v0320200.1
– Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200
Domains
24
LotjaGi3g1v0320200.2
– Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200
Domains
24
LotjaGi3g1v0320200.3
– Orotate phosphoribosyltransferase, putative; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42586|UMPS_ARATH Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|A0A151RDY2|A0A151RDY2_CAJCA Uridine 5'-monophosphate synthase; Found in the gene: LotjaGi3g1v0320200
Domains
24
LotjaGi3g1v0320200.5
– Orotidine 5'-phosphate decarboxylase; TAIR: AT3G54470.1 uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); Swiss-Prot: sp|Q42942|UMPS_TOBAC Uridine 5'-monophosphate synthase; TrEMBL-Plants: tr|K7M0S3|K7M0S3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0320200
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF51366 SUPERFAMILY 1 11.11