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IPR015405

Source: InterPro

Description

IPR015405 is a NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like.

<p>This entry represents a domain found at the C-terminal end of various NADH dehydrogenases from bacteria and eukaryotes, including NADH-quinone oxidoreductase subunit G from Rickettsia typhi (NuoG) and NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial from humans (NDUFS1, also known as Complex I-75kD, CI-75kD).</p> <p>NuoG shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</p> <p>NDUFS1 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor [[cite:PUB00103529], [cite:PUB00103528]]. This protein is associated with mitochondrial disorders leading to a group of highly heterogeneous conditions ranging from lethal neonatal disease to adult-onset neurodegenerative disorders [[cite:PUB00103528], [cite:PUB00103530]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016651
Molecular function Oxidoreductase activity, acting on NAD(P)H Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
Subterm of
GO:0051536
Molecular function Iron-sulfur cluster binding Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj6g3v0409410.1
– PREDICTED: NADH dehydrogenase [ubiquinone] gi|356539814|ref|XP_003538388.1|
Domains
29
LotjaGi6g1v0054900.1
– NADH-ubiquinone oxidoreductase subunit; TAIR: AT5G37510.1 NADH-ubiquinone dehydrogenase; Swiss-Prot: sp|Q43644|NDUS1_SOLTU NADH dehydrogenase [ubiquinone] iron-sulfur protein 1, mitochondrial; TrEMBL-Plants: tr|A0A0S3RZR3|A0A0S3RZR3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0054900
Domains
31

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00