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IPR019574 is a NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding.
<p>This entry represents the iron-sulphur binding domain of the G subunit. This domain consists of just two α-helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues [[cite:PUB00053330], [cite:PUB00087088], [cite:PUB00087089]].</p> <p>This domain is found in the G subunit (one of 14 subunits, A to N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria while translocating protons, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. It is also found in subunits from formate dehydrogenase complexes, in particular, the NADP(+)-dependent formate dehydrogenase subunit alpha which is involved in the NADP-dependent reduction of CO2 to format [[cite:PUB00155460]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: NADH dehydrogenase [ubiquinone] gi|356539814|ref|XP_003538388.1| | 29 | ||
| – | NADH-ubiquinone oxidoreductase subunit; TAIR: AT5G37510.1 NADH-ubiquinone dehydrogenase; Swiss-Prot: sp|Q43644|NDUS1_SOLTU NADH dehydrogenase [ubiquinone] iron-sulfur protein 1, mitochondrial; TrEMBL-Plants: tr|A0A0S3RZR3|A0A0S3RZR3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0054900 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |