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IPR023019 is a Histidine biosynthesis bifunctional protein HisIE.
<p>The HisI and HisE functions, phosphoribosyl-AMP cyclohydrolase [ec:3.5.4.19] and phosphoribosyl-ATP pyrophosphatase [ec:3.6.1.31], are coded by a a single gene in E. coli and other bacteria [[cite:PUB00053975]]. This entry represents bifunctional HisIE proteins. This entry also includes its plant homologues, such as HISN2 (At1g31860) from Arabidopsis [[cite:PUB00074101]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. | ||
| Molecular function | Phosphoribosyl-AMP cyclohydrolase activity | Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. | ||
| Molecular function | Phosphoribosyl-ATP diphosphatase activity | Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: histidine biosynthesis bifunctional protein hisIE, chloroplastic-like isoform X2 [Cicer arietinum] gi|502106940|ref|XP_004493105.1| | 16 | ||
| – | PREDICTED: histidine biosynthesis bifunctional protein hisIE, chloroplastic-like isoform X2 [Cicer arietinum] gi|502106940|ref|XP_004493105.1| | 16 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi1g1v0635100 | 17 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi1g1v0635100 | 17 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi2g1v0231900 | 17 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi2g1v0231900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11534 | CDD | 1 | 16.67 |