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IPR008179 is a Phosphoribosyl-ATP pyrophosphohydrolase.
<p>Phosphoribosyl-ATP pyrophosphatase, [ec:3.6.1.31] catalyses the second step in the histidine biosynthetic pathway [[cite:PUB00070280]]:</p> <reaction>5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + PPi</reaction> <p>In E. coli, HisIE is encoded by the hisIE gene, which is formed by hisE gene fused to hisl [[cite:PUB00080203]]. HisIE is a bifunctional enzyme responsible for the second and third steps of the histidine-biosynthesis pathway. Its N-terminal and C-terminal domains have phosphoribosyl-AMP cyclohydrolase (HisI) and phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) activity, respectively. This family corresponds to the C-terminal domain of HisIE and includes many hisE gene encoding proteins, all of which show significant sequence similarity to Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH). These proteins may be responsible for only the second step in the histidine-biosynthetic pathway, irreversibly hydrolyzing phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate [[cite:PUB00079689], [cite:PUB00079704], [cite:PUB00046911], [cite:PUB00003234], [cite:PUB00080202], [cite:PUB00074101], [cite:PUB00053975], [cite:PUB00080204], [cite:PUB00079795], [cite:PUB00080205], [cite:PUB00080206], [cite:PUB00080207], [cite:PUB00001753]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. | ||
| Molecular function | Phosphoribosyl-ATP diphosphatase activity | Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: histidine biosynthesis bifunctional protein hisIE, chloroplastic-like isoform X2 [Cicer arietinum] gi|502106940|ref|XP_004493105.1| | 16 | ||
| – | PREDICTED: histidine biosynthesis bifunctional protein hisIE, chloroplastic-like isoform X2 [Cicer arietinum] gi|502106940|ref|XP_004493105.1| | 16 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi1g1v0635100 | 17 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A151T975|A0A151T975_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0635100 | 15 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi1g1v0635100 | 17 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi2g1v0231900 | 17 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A151T975|A0A151T975_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0231900 | 15 | ||
| – | Phosphoribosyl-AMP cyclohydrolase; TAIR: AT1G31860.1 histidine biosynthesis bifunctional protein (HISIE); Swiss-Prot: sp|O82768|HIS2_ARATH Histidine biosynthesis bifunctional protein hisIE, chloroplastic; TrEMBL-Plants: tr|A0A072U2X9|A0A072U2X9_MEDTR Histidine biosynthesis hisIE protein; Found in the gene: LotjaGi2g1v0231900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11534 | CDD | 1 | 12.50 |