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IPR023026 is a Tryptophan synthase beta chain/beta chain-like.
<p>Tryptophan synthase catalyses the last step in the biosynthesis of tryptophan [[cite:PUB00000116], [cite:PUB00000769]]:</p> <p><reaction>L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H<sub>2</sub>O</reaction></p> <p>It has two functional domains, each found in bacteria and plants on a separate subunit: alpha chain ([interpro:IPR002028]) is for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate and beta chain is for the synthesis of tryptophan from indole and serine. In fungi the two domains are fused together on a single multifunctional protein [[cite:PUB00004683]].</p> <p>The beta chain of the enzyme, represented here, requires pyridoxal-phosphate as a cofactor. The pyridoxal-phosphate group is attached to a lysine residue. The region around this lysine residue also contains two histidine residues which are part of the pyridoxal-phosphate binding site.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Tryptophan biosynthetic process | The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. | ||
| Molecular function | Tryptophan synthase activity | Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: tryptophan synthase beta chain 2, chloroplastic-like [Cicer arietinum] gi|502128685|ref|XP_004500046.1| | 15 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: tryptophan synthase beta chain 2-like [Cicer arietinum] gi|502148742|ref|XP_004507251.1| | 11 | ||
| – | PREDICTED: tryptophan synthase beta chain 2, chloroplastic-like [Glycine max] gi|356567382|ref|XP_003551899.1| | 14 | ||
| – | Tryptophan synthase beta chain; TAIR: AT5G38530.1 tryptophan synthase beta type 2; Swiss-Prot: sp|Q8Q001|TRPB2_METMA Tryptophan synthase beta chain 2; TrEMBL-Plants: tr|A0A072U669|A0A072U669_MEDTR Tryptophan synthase beta chain; Found in the gene: LotjaGi2g1v0059100 | 16 | ||
| – | Tryptophan synthase beta chain; TAIR: AT5G38530.1 tryptophan synthase beta type 2; Swiss-Prot: sp|Q8Q001|TRPB2_METMA Tryptophan synthase beta chain 2; TrEMBL-Plants: tr|A0A072U669|A0A072U669_MEDTR Tryptophan synthase beta chain; Found in the gene: LotjaGi2g1v0059100 | 16 | ||
| – | Tryptophan synthase, beta chain; TAIR: AT5G28237.1 Pyridoxal-5'-phosphate-dependent enzyme family protein; Swiss-Prot: sp|O50046|TRPB_CAMAC Tryptophan synthase beta chain 2, chloroplastic; TrEMBL-Plants: tr|A0A0S3T6G8|A0A0S3T6G8_PHAAN Tryptophan synthase; Found in the gene: LotjaGi2g1v0457700 | 15 | ||
| – | Tryptophan synthase beta chain; TAIR: AT4G27070.1 tryptophan synthase beta-subunit 2; Swiss-Prot: sp|P25269|TRBP2_ARATH Tryptophan synthase beta chain 2, chloroplastic; TrEMBL-Plants: tr|I1N0T6|I1N0T6_SOYBN Tryptophan synthase; Found in the gene: LotjaGi6g1v0162700 | 15 | ||
| – | Tryptophan synthase beta chain; TAIR: AT4G27070.1 tryptophan synthase beta-subunit 2; Swiss-Prot: sp|O50046|TRPB_CAMAC Tryptophan synthase beta chain 2, chloroplastic; TrEMBL-Plants: tr|I3S5I7|I3S5I7_LOTJA Tryptophan synthase; Found in the gene: LotjaGi6g1v0166000 | 16 | ||
| – | Tryptophan synthase beta chain; TAIR: AT4G27070.1 tryptophan synthase beta-subunit 2; Swiss-Prot: sp|O50046|TRPB_CAMAC Tryptophan synthase beta chain 2, chloroplastic; TrEMBL-Plants: tr|I3S5I7|I3S5I7_LOTJA Tryptophan synthase; Found in the gene: LotjaGi6g1v0166000 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |