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IPR026182

Source: InterPro

Description

IPR026182 is a Anaphase-promoting complex subunit 15.

<p>Human ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C; it is not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. It also required for degradation of CDC20 [[cite:PUB00060168]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005680
Cellular component Anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Subterm of
GO:0090266
Biological process Regulation of mitotic cell cycle spindle assembly checkpoint Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
Subterm of
Regulates

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0201039.1
– PREDICTED: anaphase-promoting complex subunit 15-like isoform X1 [Cicer arietinum] gi|502133743|ref|XP_004501876.1|
Domains
5
LotjaGi1g1v0196500.1
– Peptide chain release factor 2; TAIR: AT5G63135.1 transcription termination factor; Swiss-Prot: sp|Q54GU0|ARSB_DICDI Putative transporter arsB; TrEMBL-Plants: tr|A0A151TRF8|A0A151TRF8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0196500
Domains
4

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00