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IPR026541 is a MRG domain.
<p>MORF4 (mortality factor on chromosome 4), MRG15 (MORF4-related gene on chromosome 15) and MRGX (MORF4-related gene on chromosome X) are members of the MRG protein family that were first identified as transcription factors involved in cellular senescence. All expressed members of the MRG family are localized to the nucleus and have predicted motifs that indicate they function as chromatin remodeling complex components. MORF4, MRG15 and MRGX share a common C-terminal part but a different N-terminal part. The C-terminal similarity of all MRG family members (MORF4, MRG15 and MRGX homologues) defines a new conserved protein domain. The ~170 amino acid MRG domain binds a plethora of transcriptional regulators and chromatin-remodeling factors, including the histone deacetylase transcriptional corepressor mSin3A and the nuclear protein PAM14 (protein-associated MRG, 14kDa) [[cite:PUB00060506], [cite:PUB00011581]].</p> <p>The MRG domain consists of three conserved blocks. It is predominantly hydrophobic, and consists of mainly α-helices that are arranged in a three layer sandwich topology. The hydrophobic core is stabilised by interactions among a number of conserved hydrophobic residues. The molecular surface is largely hydrophobic, but contains a few hydrophilic patches [[cite:PUB00039369], [cite:PUB00040544], [cite:PUB00059658]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nuA4 complex subunit EAF3 homolog [Glycine max] gi|356510513|ref|XP_003523982.1| | 7 | ||
| – | PREDICTED: nuA4 complex subunit EAF3 homolog [Glycine max] gi|356511911|ref|XP_003524665.1| | 10 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT1G02740.1 MRG family protein; Swiss-Prot: sp|Q4V3E2|MRG2_ARATH Protein MRG2; TrEMBL-Plants: tr|A0A151TTR4|A0A151TTR4_CAJCA Chromatin modification-related protein eaf3; Found in the gene: LotjaGi1g1v0358500 | 9 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT1G02740.1 MRG family protein; Swiss-Prot: sp|Q4V3E2|MRG2_ARATH Protein MRG2; TrEMBL-Plants: tr|A0A0B2PA75|A0A0B2PA75_GLYSO Chromatin modification-related protein EAF3; Found in the gene: LotjaGi1g1v0358500 | 16 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0099900 | 9 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0099900 | 9 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0099900 | 14 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0100000_LC | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |