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IPR008676 is a MRG.
<p>This entry represents MRG protein family, whose members include MORF4L1/2 (MRG15/MRGX) and MSL3L1/2 from humans, ESA1-associated factor 3 (Eaf3) from yeasts and male-specific lethal 3 (MSL3) from flies. They contain an N-terminal chromodomain that binds H3K36me3, a histone mark associated with transcription elongation [[cite:PUB00074565]].</p> <p>Saccharomyces cerevisiae Eaf3 is a component of both NuA4 histone acetyltransferase and Rpd3S histone deacetylase complexes [[cite:PUB00017120], [cite:PUB00060510]]. It was found that Eaf3 mediates preferential deacetylation of coding regions through an interaction between the Eaf3 chromodomain and methylated H3-K36 that presumably results in preferential association of the Rpd3 complex [[cite:PUB00060511]].</p> <p>The Drosophila MSL proteins (MSL1, MSL2, MSL3, MLE, and MOF) are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation) [[cite:PUB00074562]]. Together with two partly redundant non-coding RNAs, roX1 and roX2, they form the MSL complex, also known as dosage compensation complex or DCC. MSL complex upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark [[cite:PUB00074563]] and allows compensation for the loss of one X-chromosomal allele by increasing the transcription from the retained allele [[cite:PUB00074561]]. The MSL3 chromodomain has been shown to bind DNA and methylated H4K20 in vitro [[cite:PUB00074563]].</p> <p>Human MORF4L1, also known as MRG15, is a component of the NuA4 histone acetyltransferase complex that transcriptional activates genes by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. NuA4 complex may also play a direct role in DNA repair when directly recruited to sites of DNA damage. MRG15 is also a component of the mSin3A/Pf1/HDAC complex which acts to repress transcription by deacetylation of nucleosomal histones. MRG15 was found to interact with PALB2, a tumour suppressor protein that plays a crucial role in DNA damage repair by homologous recombination [[cite:PUB00060512]]. Furthermore, MRG15 play a role in the response to double strand breaks (DSBs) by recruiting the BRCA complex (BRCA1, PALB2, BRCA2 and RAD51) to sites of damaged DNA [[cite:PUB00035439], [cite:PUB00060508]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | Chromatin organization | Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nuA4 complex subunit EAF3 homolog [Glycine max] gi|356510513|ref|XP_003523982.1| | 7 | ||
| – | PREDICTED: nuA4 complex subunit EAF3 homolog [Glycine max] gi|356511911|ref|XP_003524665.1| | 10 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT1G02740.1 MRG family protein; Swiss-Prot: sp|Q4V3E2|MRG2_ARATH Protein MRG2; TrEMBL-Plants: tr|A0A151TTR4|A0A151TTR4_CAJCA Chromatin modification-related protein eaf3; Found in the gene: LotjaGi1g1v0358500 | 9 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT1G02740.1 MRG family protein; Swiss-Prot: sp|Q4V3E2|MRG2_ARATH Protein MRG2; TrEMBL-Plants: tr|A0A0B2PA75|A0A0B2PA75_GLYSO Chromatin modification-related protein EAF3; Found in the gene: LotjaGi1g1v0358500 | 16 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0099900 | 9 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0099900 | 9 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0099900 | 14 | ||
| – | Mortality factor 4-like protein 1; TAIR: AT4G37280.1 MRG family protein; Swiss-Prot: sp|Q94C32|MRG1_ARATH Protein MRG1; TrEMBL-Plants: tr|I1K283|I1K283_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0100000_LC | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |