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IPR027110

Source: InterPro

Description

IPR027110 is a Pyruvate dehydrogenase E1 component subunit beta.

<p>Proteins in this family are E1 beta subunit (also known as PDB1 or PDHB) of the pyruvate dehydrogenase (PDH) complex. This PDH complex catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) [[cite:PUB00062927]]. In mitochondria the E1 enzyme exists as a heterotetramer of two E1 alpha subunits and two E1 beta subunits, with thiamine pyrophosphate as a cofactor [[cite:PUB00029081]]. Some bacteria also have E1 alpha and E1 beta subunits, found as a heterodimer of an alpha and a beta chain [[cite:PUB00063404]].</p> <p>Defects in PDHB are the cause of pyruvate dehydrogenase E1-beta deficiency (PDHBD), an enzymatic defect causing primary lactic acidosis in children [[cite:PUB00062928]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004739
Molecular function Pyruvate dehydrogenase (acetyl-transferring) activity Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
Subterm of
GO:0006086
Biological process Acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
Subterm of

Associated Lotus transcripts 17

Transcript Name Description Predicted domains Domain count
Lj1g3v1525990.1
– PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Cicer arietinum] gi|502100181|ref|XP_004491655.1|
Domains
9
Lj1g3v5062780.1
– PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Glycine max] gi|356552857|ref|XP_003544779.1|
Domains
11
Lj1g3v5062780.2
– PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Glycine max] gi|356552857|ref|XP_003544779.1|
Domains
11
Lj2g3v3188500.1
– PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Cicer arietinum] gi|502100181|ref|XP_004491655.1|
Domains
7
LotjaGi1g1v0341000_LC.1
– Pyruvate dehydrogenase E1 component subunit beta; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|P52904|ODPB_PEA Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; TrEMBL-Plants: tr|A0A0D2RG08|A0A0D2RG08_GOSRA Uncharacterized protein; Found in the gene: LotjaGi1g1v0341000_LC
Domains
6
LotjaGi1g1v0801100.1
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|Q6Z1G7|ODPB1_ORYSJ Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; TrEMBL-Plants: tr|I1JJD2|I1JJD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0801100
Domains
15
LotjaGi1g1v0801100.2
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|Q6Z1G7|ODPB1_ORYSJ Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; TrEMBL-Plants: tr|I1JJD2|I1JJD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0801100
Domains
15
LotjaGi1g1v0801100.3
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|Q6Z1G7|ODPB1_ORYSJ Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; TrEMBL-Plants: tr|I1JJD2|I1JJD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0801100
Domains
16
LotjaGi1g1v0801100.4
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|Q6Z1G7|ODPB1_ORYSJ Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; TrEMBL-Plants: tr|I1JJD2|I1JJD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0801100
Domains
15
LotjaGi1g1v0801100.5
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|Q6Z1G7|ODPB1_ORYSJ Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; TrEMBL-Plants: tr|I1JJD2|I1JJD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0801100
Domains
15
LotjaGi1g1v0801200.1
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|Q6Z1G7|ODPB1_ORYSJ Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; TrEMBL-Plants: tr|I1JJD2|I1JJD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0801200
Domains
15
LotjaGi1g1v0801200.2
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT5G50850.1 Transketolase family protein; Swiss-Prot: sp|Q6Z1G7|ODPB1_ORYSJ Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial; TrEMBL-Plants: tr|I1JJD2|I1JJD2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0801200
Domains
15
LotjaGi4g1v0360000.1
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT2G34590.1 Transketolase family protein; Swiss-Prot: sp|O64688|ODPB3_ARATH Pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic; TrEMBL-Plants: tr|I3SEX4|I3SEX4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360000
Domains
20
LotjaGi4g1v0360000.2
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT1G30120.1 pyruvate dehydrogenase E1 beta; Swiss-Prot: sp|Q9C6Z3|ODPB2_ARATH Pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic; TrEMBL-Plants: tr|I3SEX4|I3SEX4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360000
Domains
15
LotjaGi4g1v0360000.3
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT1G30120.1 pyruvate dehydrogenase E1 beta; Swiss-Prot: sp|Q9C6Z3|ODPB2_ARATH Pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic; TrEMBL-Plants: tr|I3SEX4|I3SEX4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0360000
Domains
15
LotjaGi6g1v0310500.1
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT2G34590.1 Transketolase family protein; Swiss-Prot: sp|O64688|ODPB3_ARATH Pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic; TrEMBL-Plants: tr|V7BPK8|V7BPK8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0310500
Domains
20
LotjaGi6g1v0310500.2
– 1-deoxy-D-xylulose 5-phosphate synthase 1; TAIR: AT1G30120.1 pyruvate dehydrogenase E1 beta; Swiss-Prot: sp|Q9C6Z3|ODPB2_ARATH Pyruvate dehydrogenase E1 component subunit beta-2, chloroplastic; TrEMBL-Plants: tr|A0A0L9VFW6|A0A0L9VFW6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0310500
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07036 CDD 1 5.88