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IPR033247 is a Transketolase family.
<p>Transketolase [ec:2.2.1.1] (TK) catalyses the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources [[cite:PUB00000209], [cite:PUB00000362]] show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Pichia angusta (Yeast) (Hansenula polymorpha), there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) [ec:2.2.1.3] (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.</p> <p>1-deoxyxylulose-5-phosphate synthase (DXP synthase) [[cite:PUB00004906]] is an enzyme so far found in bacteria (gene dxs) and plants (gene CLA1) which catalyses the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (dxp), a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6). DXP synthase is evolutionary related to TK. The N-terminal section, contains a histidine residue which appears to function in proton transfer during catalysis [[cite:PUB00001222]]. This entry represents the central section there are conserved acidic residues that are part of the active cleft and may participate in substrate-binding [[cite:PUB00001222]]. This group of proteins includes transketolase enzymes [ec:2.2.1.1] and 2-oxoisovalerate dehydrogenase beta subunit [swissprot:P37941] [ec:1.2.4.4]. Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Glycine max] gi|356552857|ref|XP_003544779.1| | 7 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Glycine max] gi|356523939|ref|XP_003530591.1| | 19 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Cicer arietinum] gi|502132311|ref|XP_004501298.1| | 21 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Glycine max] gi|356552857|ref|XP_003544779.1| | 7 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Cicer arietinum] gi|502100181|ref|XP_004491655.1| | 9 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Glycine max] gi|356552857|ref|XP_003544779.1| | 11 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Glycine max] gi|356552857|ref|XP_003544779.1| | 11 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Cicer arietinum] gi|502100181|ref|XP_004491655.1| | 7 | ||
| – | PREDICTED: transketolase, chloroplastic-like [Glycine max] gi|356506190|ref|XP_003521870.1| | 17 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Glycine max] gi|356529695|ref|XP_003533424.1| | 24 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like [Cicer arietinum] gi|502100181|ref|XP_004491655.1| | 7 | ||
| – | PREDICTED: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial-like [Cicer arietinum] gi|502146727|ref|XP_004506580.1| | 16 | ||
| – | PREDICTED: transketolase, chloroplastic-like [Glycine max] gi|356506190|ref|XP_003521870.1| | 20 | ||
| – | PREDICTED: transketolase, chloroplastic-like [Glycine max] gi|356506190|ref|XP_003521870.1| | 9 | ||
| – | PREDICTED: transketolase, chloroplastic-like [Glycine max] gi|356506190|ref|XP_003521870.1| | 12 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Glycine max] gi|356564868|ref|XP_003550669.1| | 8 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Glycine max] gi|356564868|ref|XP_003550669.1| | 19 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Glycine max] gi|356564868|ref|XP_003550669.1| | 9 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Cicer arietinum] gi|502151190|ref|XP_004508322.1| | 24 | ||
| – | Pyruvate dehydrogenase E1 component subunit beta [Medicago truncatula] gi|357461751|ref|XP_003601157.1| | 15 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like [Cicer arietinum] gi|502141609|ref|XP_004504563.1| | 20 | ||
| – | PREDICTED: transketolase, chloroplastic-like [Cicer arietinum] gi|502121526|ref|XP_004497357.1| | 8 | ||
| – | PREDICTED: transketolase, chloroplastic-like [Glycine max] gi|356576867|ref|XP_003556551.1| | 29 | ||
| – | Transketolase [Medicago truncatula] gi|357445031|ref|XP_003592793.1| | 17 | ||
| – | PREDICTED: probable 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic-like [Glycine max] gi|356546474|ref|XP_003541651.1| | 24 | ||
| – | PREDICTED: pyruvate dehydrogenase E1 component subunit beta-like [Glycine max] gi|356525080|ref|XP_003531155.1| | 20 | ||
| – | 1-deoxy-D-xylulose-5-phosphate synthase, Transketolase; TAIR: AT2G45290.1 Transketolase; Swiss-Prot: sp|F4IW47|TKTC2_ARATH Transketolase-2, chloroplastic; TrEMBL-Plants: tr|A0A0L9UT98|A0A0L9UT98_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0434600 | 25 | ||
| – | 1-deoxy-D-xylulose-5-phosphate synthase, Transketolase; TAIR: AT2G45290.1 Transketolase; Swiss-Prot: sp|Q43848|TKTC_SOLTU Transketolase, chloroplastic; TrEMBL-Plants: tr|A0A151RWZ7|A0A151RWZ7_CAJCA Uncharacterized protein; Found in the gene: LotjaGi5g1v0360800 | 29 | ||
| – | 1-deoxy-D-xylulose-5-phosphate synthase, Transketolase; TAIR: AT3G60750.1 Transketolase; Swiss-Prot: sp|Q43848|TKTC_SOLTU Transketolase, chloroplastic; TrEMBL-Plants: tr|A0A151RWZ7|A0A151RWZ7_CAJCA Uncharacterized protein; Found in the gene: LotjaGi5g1v0360800 | 28 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07033 | CDD | 1 | 3.45 |