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IPR028606

Source: InterPro

Description

IPR028606 is a Polyribonucleotide 5-hydroxyl-kinase Clp1.

<p>Polyribonucleotide 5-hydroxyl-kinase Clp1 is a component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation [[cite:PUB00068836]]. It is involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation [[cite:PUB00068836]]. Human Clp1 can also function as a tRNA splicing enzyme [[cite:PUB00068902], [cite:PUB00100518]]. In human, mutations in Clp1 affect tRNA biogenesis and lead to impairment of both peripheral and central nervous system function, causing severe motor-sensory defects, cortical dysgenesis and microcephaly [[cite:PUB00075574]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005849
Cellular component MRNA cleavage factor complex Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.
Subterm of
GO:0031124
Biological process MRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj5g3v2290070.2
– PREDICTED: protein CLP1 homolog [Glycine max] gi|356536520|ref|XP_003536785.1|
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00