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IPR032319 is a Clp1, P-loop domain.
<p>This entry represents the P-loop containing domain of Clp1. This domain carries the P-loop, suggesting it is the region that binds adenine or guanine nucleotide [[cite:PUB00042008]].</p> <p>Polyribonucleotide 5-hydroxyl-kinase Clp1 is a component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation [[cite:PUB00068836]]. It is involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation [[cite:PUB00068836]]. Human Clp1 can also function as a tRNA splicing enzyme [[cite:PUB00068902], [cite:PUB00100518]]. In human, mutations in Clp1 affect tRNA biogenesis and lead to impairment of both peripheral and central nervous system function, causing severe motor-sensory defects, cortical dysgenesis and microcephaly [[cite:PUB00075574]]. Clp1 contains three domains, a small N-terminal β sandwich domain involved in DNA binding [[cite:PUB00097408]], a C-terminal domain containing a novel α/β-fold and a central domain that binds ATP [[cite:PUB00042008], [cite:PUB00097409]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: polynucleotide 5'-hydroxyl-kinase NOL9-like [Glycine max] gi|356513953|ref|XP_003525672.1| | 6 | ||
| – | PREDICTED: polynucleotide 5'-hydroxyl-kinase NOL9-like [Glycine max] gi|356507198|ref|XP_003522357.1| | 3 | ||
| – | PREDICTED: polynucleotide 5'-hydroxyl-kinase NOL9-like [Glycine max] gi|356513953|ref|XP_003525672.1| | 7 | ||
| – | PREDICTED: protein CLP1 homolog [Glycine max] gi|356536520|ref|XP_003536785.1| | 13 | ||
| – | Polynucleotide 5'-hydroxyl-kinase NOL9; TAIR: AT5G11010.2 Pre-mRNA cleavage complex II protein family; Swiss-Prot: sp|Q8VYP6|NOL9_ARATH Polynucleotide 5'-hydroxyl-kinase NOL9; TrEMBL-Plants: tr|I1K1J8|I1K1J8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0185900 | 7 | ||
| – | Polynucleotide 5'-hydroxyl-kinase NOL9; TAIR: AT5G11010.2 Pre-mRNA cleavage complex II protein family; Swiss-Prot: sp|Q8VYP6|NOL9_ARATH Polynucleotide 5'-hydroxyl-kinase NOL9; TrEMBL-Plants: tr|I1K1J8|I1K1J8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0185900 | 7 | ||
| – | Polynucleotide 5'-hydroxyl-kinase NOL9; TAIR: AT5G11010.2 Pre-mRNA cleavage complex II protein family; Swiss-Prot: sp|Q8VYP6|NOL9_ARATH Polynucleotide 5'-hydroxyl-kinase NOL9; TrEMBL-Plants: tr|I1K1J8|I1K1J8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0185900 | 7 | ||
| – | Polynucleotide 5'-hydroxyl-kinase NOL9; TAIR: AT5G11010.2 Pre-mRNA cleavage complex II protein family; Swiss-Prot: sp|Q8VYP6|NOL9_ARATH Polynucleotide 5'-hydroxyl-kinase NOL9; TrEMBL-Plants: tr|I1JX12|I1JX12_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0101700_LC | 4 | ||
| – | Polynucleotide 5'-hydroxyl-kinase NOL9; TAIR: AT5G11010.2 Pre-mRNA cleavage complex II protein family; Swiss-Prot: sp|Q8VYP6|NOL9_ARATH Polynucleotide 5'-hydroxyl-kinase NOL9; TrEMBL-Plants: tr|I1JX12|I1JX12_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0101700_LC | 4 | ||
| – | Protein CLP1 homolog; TAIR: AT3G04680.1 CLP-similar protein 3; Swiss-Prot: sp|Q9SR06|CLP1_ARATH Protein CLP1 homolog; TrEMBL-Plants: tr|A0A151RWZ1|A0A151RWZ1_CAJCA Protein CLP1 homolog; Found in the gene: LotjaGi5g1v0360500 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |