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IPR010655

Source: InterPro

Description

IPR010655 is a Clp1, C-terminal.

<p>This entry represents the C-terminal domain of Clp1.</p> <p>Polyribonucleotide 5-hydroxyl-kinase Clp1 is a component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation [[cite:PUB00068836]]. It is involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation [[cite:PUB00068836]]. Human Clp1 can also function as a tRNA splicing enzyme [[cite:PUB00068902], [cite:PUB00100518]]. In human, mutations in Clp1 affect tRNA biogenesis and lead to impairment of both peripheral and central nervous system function, causing severe motor-sensory defects, cortical dysgenesis and microcephaly [[cite:PUB00075574]]. Clp1 contains three domains, a small N-terminal β sandwich domain involved in DNA binding [[cite:PUB00097408]], a C-terminal domain containing a novel α/β-fold and a central domain that binds ATP [[cite:PUB00042008], [cite:PUB00097409]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0031124
Biological process MRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj5g3v2290070.1
– PREDICTED: protein CLP1 homolog [Glycine max] gi|356536520|ref|XP_003536785.1|
Domains
3
Lj5g3v2290070.2
– PREDICTED: protein CLP1 homolog [Glycine max] gi|356536520|ref|XP_003536785.1|
Domains
13
LotjaGi5g1v0360500.4
– Protein CLP1 homolog; TAIR: AT3G04680.1 CLP-similar protein 3; Swiss-Prot: sp|Q9SR06|CLP1_ARATH Protein CLP1 homolog; TrEMBL-Plants: tr|A0A151RWZ1|A0A151RWZ1_CAJCA Protein CLP1 homolog; Found in the gene: LotjaGi5g1v0360500
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33