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IPR029491 is a Helicase Helix-turn-helix domain.
<p>This presumed domain is found at the C terminus of a large number of helicases, including human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, a multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates and also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang [[cite:PUB00155467], [cite:PUB00067645]]. Its depletion leads to chromosomal breaks and genome instability [[cite:PUB00155466]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: Werner syndrome ATP-dependent helicase homolog [Glycine max] gi|356569961|ref|XP_003553162.1| | 35 | ||
| – | PREDICTED: Werner syndrome ATP-dependent helicase-like isoform X2 [Cicer arietinum] gi|502129737|ref|XP_004500408.1| | 11 | ||
| – | ATP-dependent RNA helicase DeaD; TAIR: AT1G31360.1 RECQ helicase L2; Swiss-Prot: sp|Q9CL21|RECQ_PASMU ATP-dependent DNA helicase RecQ; TrEMBL-Plants: tr|A0A0B2QEX8|A0A0B2QEX8_GLYSO Werner syndrome ATP-dependent helicase like; Found in the gene: LotjaGi6g1v0046900 | 36 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18794 | CDD | 1 | 33.33 |