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IPR002121 is a HRDC domain.
<p>The HRDC (helicase and RNaseD C-terminal) domain is comprised of two orthogonally packed α-hairpin subdomains, and is involved in interactions with DNA and protein. It has been suggested that this domain plays a role dissolving double Holliday junctions efficiently [[cite:PUB00101132]].</p> <p>HRDC domains are found at the C terminus of many RecQ helicases, including the human Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and RecQ-like DNA helicase BLM [[cite:PUB00101132], [cite:PUB00014060]]. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. The structure of the HRDC domain consists of a 4-5 helical bundle of two orthogonally packed α-hairpins, and as such it resembles auxiliary domains in bacterial DNA helicases and other proteins that interact with nucleic acids. A positively charged region on the surface of the HRDC domain is able to interact with DNA.</p> <p>The HRDC domain is also present in eukaryotic and archaeal RNA polymerase II subunit RBP4, the N-terminal of which forms a heterodimerisation α-hairpin [[cite:PUB00032236], [cite:PUB00007873]].</p> <p>The HRDC domain has a putative role in nucleic acid binding. Mutations in the HRDC domain associated with the human BLM gene result in Bloom Syndrome (BS), an autosomal recessive disorder characterised by proportionate pre- and postnatal growth deficiency; sun-sensitive, telangiectatic, hypo- and hyperpigmented skin; predisposition to malignancy; and chromosomal instability [[cite:PUB00005473]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nucleic acid binding | Interacting selectively and non-covalently with any nucleic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: exosome component 10-like [Glycine max] gi|356565747|ref|XP_003551099.1| | 8 | ||
| – | PREDICTED: exosome component 10-like isoform X1 [Cicer arietinum] gi|502107238|ref|XP_004493202.1| | 19 | ||
| – | PREDICTED: mediator of RNA polymerase II transcription subunit 34-like [Cicer arietinum] gi|502162030|ref|XP_004512366.1| | 29 | ||
| – | PREDICTED: Werner syndrome ATP-dependent helicase homolog [Glycine max] gi|356569961|ref|XP_003553162.1| | 35 | ||
| – | PREDICTED: Werner syndrome ATP-dependent helicase-like isoform X2 [Cicer arietinum] gi|502129737|ref|XP_004500408.1| | 11 | ||
| – | Exosome complex exonuclease RRP6 [Medicago truncatula] gi|357471299|ref|XP_003605934.1| | 12 | ||
| – | Exosome complex exonuclease RRP6 [Medicago truncatula] gi|357471299|ref|XP_003605934.1| | 10 | ||
| – | Exosome complex exonuclease RRP6 [Medicago truncatula] gi|357471299|ref|XP_003605934.1| | 17 | ||
| – | 3'-5' exonuclease domain-containing family protein; TAIR: AT5G35910.1 Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain-containing protein; Swiss-Prot: sp|A9LLI7|RP6L2_ARATH Protein RRP6-like 2; TrEMBL-Plants: tr|A0A151TSU8|A0A151TSU8_CAJCA Exosome component 10; Found in the gene: LotjaGi1g1v0646900 | 20 | ||
| – | 3'-5' exonuclease domain-containing family protein; TAIR: AT5G35910.1 Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain-containing protein; Swiss-Prot: sp|A9LLI7|RP6L2_ARATH Protein RRP6-like 2; TrEMBL-Plants: tr|I1MW66|I1MW66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0108600 | 18 | ||
| – | ATP-dependent RNA helicase DeaD; TAIR: AT1G31360.1 RECQ helicase L2; Swiss-Prot: sp|Q9FT73|MED34_ARATH Mediator of RNA polymerase II transcription subunit 34; TrEMBL-Plants: tr|A0A151RUE2|A0A151RUE2_CAJCA ATP-dependent DNA helicase Q1; Found in the gene: LotjaGi2g1v0344800 | 30 | ||
| – | 3'-5' exonuclease domain protein; TAIR: AT2G32415.1 Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain-containing protein; Swiss-Prot: sp|A9LLI8|RP6L3_ARATH Protein RRP6-like 3; TrEMBL-Plants: tr|A0A151S0B7|A0A151S0B7_CAJCA Exosome complex exonuclease RRP6; Found in the gene: LotjaGi3g1v0466600 | 18 | ||
| – | ATP-dependent RNA helicase DeaD; TAIR: AT1G31360.1 RECQ helicase L2; Swiss-Prot: sp|Q9CL21|RECQ_PASMU ATP-dependent DNA helicase RecQ; TrEMBL-Plants: tr|A0A0B2QEX8|A0A0B2QEX8_GLYSO Werner syndrome ATP-dependent helicase like; Found in the gene: LotjaGi6g1v0046900 | 36 | ||
| – | ATP-dependent RNA helicase DeaD; TAIR: AT1G10930.1 DNA helicase (RECQl4A); Swiss-Prot: sp|Q8L840|RQL4A_ARATH ATP-dependent DNA helicase Q-like 4A; TrEMBL-Plants: tr|G7INR2|G7INR2_MEDTR ATP-dependent DNA helicase RecQ family protein; Found in the gene: LotjaGi6g1v0361700 | 36 | ||
| – | ATP-dependent RNA helicase DeaD; TAIR: AT1G10930.1 DNA helicase (RECQl4A); Swiss-Prot: sp|Q8L840|RQL4A_ARATH ATP-dependent DNA helicase Q-like 4A; TrEMBL-Plants: tr|G7INR2|G7INR2_MEDTR ATP-dependent DNA helicase RecQ family protein; Found in the gene: LotjaGi6g1v0361700 | 36 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |