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IPR030547 is a DNA repair protein XRCC2.
<p>DNA repair protein XRCC2 is a RAD51 paralogue. In humans, it is part of the protein complex BCDX2 (contains RAD51B, RAD51C, RAD51D, and XRCC2), which acts in the BRCA1-BRCA2-dependent homologous recombination pathway [[cite:PUB00073165], [cite:PUB00073166]]. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA [[cite:PUB00073165]]. Interestingly, XRCC2 and other homologous recombination proteins are associated with centrosomes and are required for mitotic stability [[cite:PUB00073167]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. | ||
| Cellular component | Replication fork | The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Cellular component | Rad51B-Rad51C-Rad51D-XRCC2 complex | A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA repair protein XRCC2 like; TAIR: AT5G64520.5 homolog of X-ray repair cross complementing 2 (XRCC2); Swiss-Prot: sp|Q682D3|XRCC2_ARATH DNA repair protein XRCC2 homolog; TrEMBL-Plants: tr|A0A072UXF4|A0A072UXF4_MEDTR X-ray repair cross complementing 2 (XRCC2)-like protein, putative; Found in the gene: LotjaGi3g1v0525200 | 5 | ||
| – | DNA repair protein XRCC2 like; TAIR: AT5G64520.5 homolog of X-ray repair cross complementing 2 (XRCC2); Swiss-Prot: sp|Q682D3|XRCC2_ARATH DNA repair protein XRCC2 homolog; TrEMBL-Plants: tr|A0A072UXF4|A0A072UXF4_MEDTR X-ray repair cross complementing 2 (XRCC2)-like protein, putative; Found in the gene: LotjaGi3g1v0525200 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF52540 | SUPERFAMILY | 1 | 50.00 |