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IPR033858 is a 26S Proteasome non-ATPase regulatory subunit 7/8.
<p>This entry includes lid subunits of the 26 S proteasome regulatory particles, Rpn7 (PSMD7; proteasome 26S non-ATPase subunit 7; p44), and Rpn8 (PSMD8; proteasome 26S non-ATPase subunit 8; p40; Mov34). Rpn7 is known to be critical for the integrity of the 26 S proteasome complex by establishing a correct lid structure [[cite:PUB00045323]]. It is necessary for the incorporation/anchoring of Rpn3 and Rpn12 to the lid and essential for viability and normal mitosis. Rpn7 and Rpn8 are ATP-independent components of the 19S regulator subunit, and contain the MPN structural motif on its N-terminal region. However, while they show a typical MPN metalloprotease fold and are members of peptidase family M67, they lack the canonical JAMM motif, and therefore do not show catalytic isopeptidase activity [[cite:PUB00043222]]. Rpn7 is considered a non-peptidase homologue (MEROPS identifier M67.973). It is suggested that Rpn7 function is primarily structural [[cite:PUB00045068], [cite:PUB00081447]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Proteasome regulatory particle | A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable 26S proteasome non-ATPase regulatory subunit 7-like [Cicer arietinum] gi|502137923|ref|XP_004503231.1| | 9 | ||
| – | PREDICTED: probable 26S proteasome non-ATPase regulatory subunit 7-like [Glycine max] gi|356539941|ref|XP_003538451.1| | 9 | ||
| – | Eukaryotic translation initiation factor 3 subunit F; TAIR: AT5G05780.1 RP non-ATPase subunit 8A; Swiss-Prot: sp|O24412|PSD7A_ARATH 26S proteasome non-ATPase regulatory subunit 7 homolog A; TrEMBL-Plants: tr|V7CZG2|V7CZG2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0080300 | 15 | ||
| – | Eukaryotic translation initiation factor 3 subunit F; TAIR: AT5G05780.2 RP non-ATPase subunit 8A; Swiss-Prot: sp|O24412|PSD7A_ARATH 26S proteasome non-ATPase regulatory subunit 7 homolog A; TrEMBL-Plants: tr|I1LMP2|I1LMP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0080300 | 15 | ||
| – | Eukaryotic translation initiation factor 3 subunit F; TAIR: AT5G05780.1 RP non-ATPase subunit 8A; Swiss-Prot: sp|O24412|PSD7A_ARATH 26S proteasome non-ATPase regulatory subunit 7 homolog A; TrEMBL-Plants: tr|I1LMP2|I1LMP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0080300 | 15 | ||
| – | Eukaryotic translation initiation factor 3 subunit F; TAIR: AT5G05780.1 RP non-ATPase subunit 8A; Swiss-Prot: sp|O24412|PSD7A_ARATH 26S proteasome non-ATPase regulatory subunit 7 homolog A; TrEMBL-Plants: tr|I3S3L3|I3S3L3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0070800 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08062 | CDD | 1 | 16.67 |