Description

IPR034149 is a DNA topoisomerase 1, TOPRIM domain.

<p>This topoisomerase-primase (TOPRIM) domain is found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break, and allowing the other strand of the duplex to pass through the gap [[cite:PUB00020798]]. E. coli DNA topoisomerase I is primarily involved in the relaxation of negatively supercoiled DNA by the stand passage mechanism [[cite:PUB00082770]].</p> <p>The TOPRIM domain has two conserved motifs, one of which centres at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg²⁺, a cofactor required for full catalytic function [[cite:PUB00004485]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: