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IPR035420 is a Spt6, SH2 domain.
<p>This entry represents the SH2 domain found in Spt6.</p> <p>Spt6 is an essential transcription elongation factor and histone chaperone that binds the C-terminal repeat domain (CTD) of RNA polymerase II [[cite:PUB00084847]]. Spt6 contains a tandem SH2 domain with a novel structure and CTD-binding mode. The tandem SH2 domain binds to a serine 2-phosphorylated CTD peptide in vitro, whereas its N-terminal SH2 subdomain does not. CTD binding requires a positively charged crevice in the C-terminal SH2 subdomain, which lacks the canonical phospho-binding pocket of SH2 domains. The tandem SH2 domain is apparently required for transcription elongation in vivo as its deletion in cells is lethal in the presence of 6-azauracil. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [[cite:PUB00065554]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|I1N8M6|I1N8M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0657000 | 45 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|I1N8M6|I1N8M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0657000 | 47 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 42 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|Q9CAM1|SPT62_ARATH Transcription elongation factor SPT6-like; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
| – | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.14 |