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IPR017072 is a Transcription elongation factor Spt6.
<p>Spt6 is an essential histone chaperone that mediates nucleosome reassembly during gene transcription. The N-terminal ~300 residues are highly acidic, predicted to be disordered, and are necessary for binding both nucleosomes and the transcription factor Spn1/IWS1 [[cite:PUB00065451]]. Spt6 associates with RNAPII via a tandem Src2 homology domain [[cite:PUB00059511], [cite:PUB00089793]]. Spt6-RNAPII association is required for efficient recruitment of the Ccr4-Not de-adenylation complex to transcribed genes for mRNA turnover [[cite:PUB00089792]]. Spt6 has a key function in transcription elongation. In yeast, Spt6's interaction with phosphorylated tyrosine 1 at the C-terminal domain of RNAPII prevents pre-mature recruitment of termination factors to genes [[cite:PUB00089795]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Biological process | Positive regulation of transcription elongation from RNA polymerase II promoter | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: transcription elongation factor SPT6-like [Cicer arietinum] gi|502127604|ref|XP_004499769.1| | 37 | ||
– | PREDICTED: transcription elongation factor SPT6-like [Cicer arietinum] gi|502127604|ref|XP_004499769.1| | 37 | ||
– | PREDICTED: transcription elongation factor SPT6-like isoform X2 [Cicer arietinum] gi|502107599|ref|XP_004493315.1| | 37 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|I1N8M6|I1N8M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0657000 | 45 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|I1N8M6|I1N8M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0657000 | 47 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 42 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|Q9CAM1|SPT62_ARATH Transcription elongation factor SPT6-like; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.2 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 | ||
– | Transcription elongation factor SPT6; TAIR: AT1G65440.1 global transcription factor group B1; Swiss-Prot: sp|A8MS85|SPT61_ARATH Transcription elongation factor SPT6 homolog; TrEMBL-Plants: tr|A0A1J7IEI3|A0A1J7IEI3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0103300 | 41 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 5.88 |