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IPR036738

Source: InterPro

Description

IPR036738 is a FKBP12-rapamycin binding domain superfamily.

<p>The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the Tor proteins.</p> <p>This superfamily represents the FRB domain [[cite:PUB00013231], [cite:PUB00078108]]. Proteins containing this domain include Tor proteins which are serine/threonine kinases conserved from fungi to humans. While higher eukaryotes such as humans possess a single Tor protein, yeasts contain two (Tor1 and Tor2) [[cite:PUB00078109]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0044877
Molecular function Protein-containing complex binding Interacting selectively and non-covalently with a macromolecular complex.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0459200.1
– Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|I1LFQ6|I1LFQ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200
Domains
37
LotjaGi2g1v0459200.2
– Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|A0A0R0LMJ1|A0A0R0LMJ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200
Domains
33

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd05169 CDD 1 50.00