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IPR018936 is a Phosphatidylinositol 3/4-kinase, conserved site.
<p>Phosphatidylinositol 3-kinase (PI3-kinase) ([ec:2.7.1.137]) [[cite:PUB00000875]] is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The three products of PI3-kinase - PI-3-P, PI-3,4-P(2) and PI-3,4,5-P(3) function as secondary messengers in cell signalling. Phosphatidylinositol 4-kinase (PI4-kinase) ([ec:2.7.1.67]) [[cite:PUB00001254]] is an enzyme that acts on phosphatidylinositol (PI) in the first committed step in the production of the secondary messenger inositol-1'4'5'-trisphosphate. This domain is also present in a wide range of protein kinases, involved in diverse cellular functions, such as control of cell growth, regulation of cell cycle progression, a DNA damage checkpoint, recombination, and maintenance of telomere length. Despite significant homology to lipid kinases, no lipid kinase activity has been demonstrated for any of the PIK-related kinases [[cite:PUB00014536]].</p> <p>The PI3- and PI4-kinases share a well conserved domain at their C-terminal section; this domain seems to be distantly related to the catalytic domain of protein kinases [[cite:PUB00000893], [cite:PUB00007087]]. The catalytic domain of PI3/PI4KK has the typical bilobal structure that is seen in other ATP-dependent kinases, divided into an N-lobe and a C-lobe ([pdbe:4HNE]) [[cite:PUB00090062]]. The core of this domain is the most conserved region of the PI3Ks. The N-lobe contains a five-stranded antiparallel β-sheet core flanked by a helical hairpin on one side and a helix on the other. The C-lobe contains helices, which form a helical bundle together with the N--obe helix. The helical bundle is flanked by three β-strands and a helix. Three loops are related to kinase activity, the glycine-rich G-loop, the catalytic loop and the activation loop. The G-loop has been reported to bind to the phosphate group of nucleotides [[cite:PUB00090062]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1| | 32 | ||
| – | PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1| | 32 | ||
| – | PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1| | 33 | ||
| – | PREDICTED: phosphatidylinositol 4-kinase beta 1-like isoform X3 [Cicer arietinum] gi|502137006|ref|XP_004502930.1| | 16 | ||
| – | PREDICTED: phosphatidylinositol 4-kinase beta 1-like isoform X3 [Cicer arietinum] gi|502137006|ref|XP_004502930.1| | 18 | ||
| – | PREDICTED: phosphatidylinositol 4-kinase beta 1-like [Glycine max] gi|356525675|ref|XP_003531449.1| | 15 | ||
| – | PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 1 [Glycine max] gi|356508450|ref|XP_003522970.1| | 22 | ||
| – | PREDICTED: phosphatidylinositol 4-kinase alpha-like isoform 1 [Glycine max] gi|356508450|ref|XP_003522970.1| | 22 | ||
| – | PREDICTED: phosphatidylinositol 3-kinase, root isoform-like isoform X1 [Cicer arietinum] gi|502092928|ref|XP_004489830.1| | 33 | ||
| – | PREDICTED: serine/threonine-protein kinase SMG1 [Glycine max] gi|356541123|ref|XP_003539032.1| | 22 | ||
| – | PREDICTED: serine/threonine-protein kinase SMG1 [Glycine max] gi|356541123|ref|XP_003539032.1| | 18 | ||
| – | PREDICTED: serine/threonine-protein kinase SMG1 [Glycine max] gi|356541123|ref|XP_003539032.1| | 16 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase ATM-like [Cicer arietinum] gi|502133902|ref|XP_004501929.1| | 17 | ||
| – | PREDICTED: phosphatidylinositol 4-kinase beta 1-like [Glycine max] gi|356525675|ref|XP_003531449.1| | 15 | ||
| – | PREDICTED: serine/threonine-protein kinase ATR-like [Glycine max] gi|356534437|ref|XP_003535761.1| | 28 | ||
| – | Serine/threonine-protein kinase; TAIR: AT3G48190.2 Serine/Threonine-kinase ATM-like protein; Swiss-Prot: sp|Q9M3G7|ATM_ARATH Serine/threonine-protein kinase ATM; TrEMBL-Plants: tr|A0A0R0KG32|A0A0R0KG32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0180100 | 29 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG9|K7KLG9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 21 | ||
| – | Phosphatidylinositol 4-kinase, putative; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG8|K7KLG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 13 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG9|K7KLG9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 21 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG8|K7KLG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 21 | ||
| – | Phosphatidylinositol 4-kinase, putative; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG8|K7KLG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 13 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG8|K7KLG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 21 | ||
| – | Phosphatidylinositol 4-kinase, putative; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG8|K7KLG8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 13 | ||
| – | Phosphatidylinositol 4-kinase; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|K7KLG9|K7KLG9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0318700 | 17 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT1G49340.1 Phosphatidylinositol 3- and 4-kinase family protein; Swiss-Prot: sp|Q9SXA1|P4KA1_ARATH Phosphatidylinositol 4-kinase alpha 1; TrEMBL-Plants: tr|I1JSQ3|I1JSQ3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0570200 | 24 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT1G49340.1 Phosphatidylinositol 3- and 4-kinase family protein; Swiss-Prot: sp|Q9SXA1|P4KA1_ARATH Phosphatidylinositol 4-kinase alpha 1; TrEMBL-Plants: tr|I1JSQ3|I1JSQ3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0570200 | 24 | ||
| – | Phosphatidylinositol 3-kinase; TAIR: AT1G60490.1 vacuolar protein sorting 34; Swiss-Prot: sp|P42347|PI3K1_SOYBN Phosphatidylinositol 3-kinase, root isoform; TrEMBL-Plants: tr|A0A151TLR0|A0A151TLR0_CAJCA Phosphatidylinositol 3-kinase, root isoform; Found in the gene: LotjaGi2g1v0321200 | 37 | ||
| – | Phosphatidylinositol 3-kinase; TAIR: AT1G60490.1 vacuolar protein sorting 34; Swiss-Prot: sp|P42347|PI3K1_SOYBN Phosphatidylinositol 3-kinase, root isoform; TrEMBL-Plants: tr|A0A151TLR0|A0A151TLR0_CAJCA Phosphatidylinositol 3-kinase, root isoform; Found in the gene: LotjaGi2g1v0321200 | 29 | ||
| – | Phosphatidylinositol 3-kinase; TAIR: AT1G60490.1 vacuolar protein sorting 34; Swiss-Prot: sp|P42347|PI3K1_SOYBN Phosphatidylinositol 3-kinase, root isoform; TrEMBL-Plants: tr|A0A151TLR0|A0A151TLR0_CAJCA Phosphatidylinositol 3-kinase, root isoform; Found in the gene: LotjaGi2g1v0321200 | 29 | ||
| – | Phosphatidylinositol 3-kinase; TAIR: AT1G60490.1 vacuolar protein sorting 34; Swiss-Prot: sp|P42347|PI3K1_SOYBN Phosphatidylinositol 3-kinase, root isoform; TrEMBL-Plants: tr|A0A151TLR0|A0A151TLR0_CAJCA Phosphatidylinositol 3-kinase, root isoform; Found in the gene: LotjaGi2g1v0321200 | 37 | ||
| – | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|I1LFQ6|I1LFQ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200 | 37 | ||
| – | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|A0A0R0LMJ1|A0A0R0LMJ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200 | 33 | ||
| – | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q8BKX6|SMG1_MOUSE Serine/threonine-protein kinase SMG1; TrEMBL-Plants: tr|K7LPC3|K7LPC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0502700 | 28 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 20 | ||
| – | Phosphatidylinositol 4-kinase, putative; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 15 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 20 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 20 | ||
| – | Phosphatidylinositol 4-kinase; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|I1KTP1|I1KTP1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0409200 | 16 | ||
| – | Phosphatidylinositol 4-kinase, putative; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 15 | ||
| – | Phosphatidylinositol 4-kinase, putative; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 20 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 20 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 20 | ||
| – | Phosphatidylinositol 4-kinase family protein; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 20 | ||
| – | Phosphatidylinositol 4-kinase, putative; TAIR: AT5G64070.1 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|A0A0B2RP37|A0A0B2RP37_GLYSO Phosphatidylinositol 4-kinase beta 1; Found in the gene: LotjaGi4g1v0409200 | 15 | ||
| – | Phosphatidylinositol 4-kinase; TAIR: AT5G64070.2 phosphatidylinositol 4-OH kinase beta1; Swiss-Prot: sp|Q9FMJ0|P4KB1_ARATH Phosphatidylinositol 4-kinase beta 1; TrEMBL-Plants: tr|G7JBJ1|G7JBJ1_MEDTR Phosphatidylinositol 4-kinase beta; Found in the gene: LotjaGi4g1v0409200 | 15 | ||
| – | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 27 | ||
| – | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 28 | ||
| – | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00892 | CDD | 1 | 2.08 |