Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR003152 is a FATC domain.
<p>Phosphatidylinositol kinase (PIK)-related kinases participate in meiotic and V(D)J recombination, chromosome maintenance and repair, cell cycle progression, and cell cycle checkpoints, and their dysfunction can result in a range of diseases, including immunodeficiency, neurological disorder and cancer. The catalytic kinase domain is highly homologuous to that of phosphatidylinositol 3- and 4-kinases. Nevertheless, members of the PIK-related family appear functionally distinct, as none of them has been shown to phosphorylate lipids, such as phosphatidylinositol; instead, many have Ser/Thr protein kinase activity. The PI-kinase domain of members of the PIK-related family is wedged between the ~550-amino acid-long FAT (FRAP, ATM, TRRAP) domain [[cite:PUB00033610]] and the ~35 residue C-terminal FATC domain [[cite:PUB00006515]].</p> <p>It has been proposed that the FAT domain could be of importance as a structural scaffold or as a protein-binding domain, or both [[cite:PUB00033610]].</p> <p>The TOR1 FATC domain, in its oxidized form, consists of an α-helix and a well structured COOH-terminal disulfide-bonded loop. Reduction of the disulfide bond dramatically increases the flexibility within the COOH-terminal loop region. The reduction may alter the binding behavior of FATC to its partners [[cite:PUB00021047]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: transformation/transcription domain-associated protein-like isoform X1 [Cicer arietinum] gi|502161350|ref|XP_004512131.1| | 25 | ||
– | PREDICTED: transformation/transcription domain-associated protein-like isoform X1 [Cicer arietinum] gi|502161350|ref|XP_004512131.1| | 25 | ||
– | PREDICTED: serine/threonine-protein kinase SMG1 [Glycine max] gi|356541123|ref|XP_003539032.1| | 22 | ||
– | PREDICTED: serine/threonine-protein kinase ATR-like [Glycine max] gi|356534437|ref|XP_003535761.1| | 28 | ||
– | PREDICTED: transformation/transcription domain-associated protein-like [Glycine max] gi|356496647|ref|XP_003517177.1| | 24 | ||
– | Serine/threonine-protein kinase; TAIR: AT3G48190.2 Serine/Threonine-kinase ATM-like protein; Swiss-Prot: sp|Q9M3G7|ATM_ARATH Serine/threonine-protein kinase ATM; TrEMBL-Plants: tr|A0A0R0KG32|A0A0R0KG32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0180100 | 29 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q8I8U7|TRA1_DROME Transcription-associated protein 1; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q8I8U7|TRA1_DROME Transcription-associated protein 1; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q8I8U7|TRA1_DROME Transcription-associated protein 1; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
– | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|I1LFQ6|I1LFQ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200 | 37 | ||
– | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|A0A0R0LMJ1|A0A0R0LMJ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200 | 33 | ||
– | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q8BKX6|SMG1_MOUSE Serine/threonine-protein kinase SMG1; TrEMBL-Plants: tr|K7LPC3|K7LPC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0502700 | 28 | ||
– | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 27 | ||
– | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 28 | ||
– | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 27 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 26 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 31 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 26 | ||
– | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 5.00 |