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IPR014009 is a PIK-related kinase.
<p>Phosphatidylinositol kinase (PIK)-related kinases participate in meiotic and V(D)J recombination, chromosome maintenance and repair, cell cycle progression, and cell cycle checkpoints, and their dysfunction can result in a range of diseases, including immunodeficiency, neurological disorder and cancer. The catalytic kinase domain is highly homologous to that of phosphatidylinositol 3- and 4-kinases. Nevertheless, members of the PIK-related family appear functionally distinct, as none of them has been shown to phosphorylate lipids, such as phosphatidylinositol; instead, many have Ser/Thr protein kinase activity. The PI-kinase domain of members of the PIK-related family is wedged between the ~550-amino acid-long FAT (FRAP, ATM, TRRAP) domain [[cite:PUB00033610]] and the ~35 residue C-terminal FATC domain [[cite:PUB00006515]].</p> <p>It has been proposed that the FAT domain could be of importance as a structural scaffold or as a protein-binding domain, or both [[cite:PUB00033610]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1| | 32 | ||
| – | PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1| | 32 | ||
| – | PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1| | 33 | ||
| – | PREDICTED: transformation/transcription domain-associated protein-like isoform X1 [Cicer arietinum] gi|502161350|ref|XP_004512131.1| | 25 | ||
| – | PREDICTED: transformation/transcription domain-associated protein-like isoform X1 [Cicer arietinum] gi|502161350|ref|XP_004512131.1| | 25 | ||
| – | PREDICTED: serine/threonine-protein kinase SMG1 [Glycine max] gi|356541123|ref|XP_003539032.1| | 22 | ||
| – | PREDICTED: serine/threonine-protein kinase SMG1 [Glycine max] gi|356541123|ref|XP_003539032.1| | 18 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase ATM-like [Cicer arietinum] gi|502133902|ref|XP_004501929.1| | 17 | ||
| – | PREDICTED: serine/threonine-protein kinase ATR-like [Glycine max] gi|356534437|ref|XP_003535761.1| | 28 | ||
| – | PREDICTED: transformation/transcription domain-associated protein-like [Glycine max] gi|356496647|ref|XP_003517177.1| | 24 | ||
| – | Serine/threonine-protein kinase; TAIR: AT3G48190.2 Serine/Threonine-kinase ATM-like protein; Swiss-Prot: sp|Q9M3G7|ATM_ARATH Serine/threonine-protein kinase ATM; TrEMBL-Plants: tr|A0A0R0KG32|A0A0R0KG32_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0180100 | 29 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q8I8U7|TRA1_DROME Transcription-associated protein 1; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q8I8U7|TRA1_DROME Transcription-associated protein 1; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q8I8U7|TRA1_DROME Transcription-associated protein 1; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|V7CI88|V7CI88_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0381400 | 23 | ||
| – | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|I1LFQ6|I1LFQ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200 | 37 | ||
| – | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|A0A0R0LMJ1|A0A0R0LMJ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200 | 33 | ||
| – | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q8BKX6|SMG1_MOUSE Serine/threonine-protein kinase SMG1; TrEMBL-Plants: tr|K7LPC3|K7LPC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0502700 | 28 | ||
| – | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 27 | ||
| – | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 28 | ||
| – | Serine/threonine-protein kinase; TAIR: AT5G40820.2 Ataxia telangiectasia-mutated and RAD3-like protein; Swiss-Prot: sp|Q9FKS4|ATR_ARATH Serine/threonine-protein kinase ATR; TrEMBL-Plants: tr|A0A0B2RY81|A0A0B2RY81_GLYSO Serine/threonine-protein kinase ATR; Found in the gene: LotjaGi5g1v0351400 | 27 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 26 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 31 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 26 | ||
| – | Transcription-associated protein 1; TAIR: AT2G17930.1 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain-containing protein; Swiss-Prot: sp|Q9Y4A5|TRRAP_HUMAN Transformation/transcription domain-associated protein; TrEMBL-Plants: tr|A0A1J7GST8|A0A1J7GST8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0032900 | 31 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 4.00 |