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IPR009076

Source: InterPro

Description

IPR009076 is a FKBP12-rapamycin binding domain.

<p>The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the Tor proteins.</p> <p>In budding yeast, the Tor2 protein exists in two distinct multi-component complexes, TORC1 and TORC2. TORC1 regulates cell growth by regulating many growth-related processes and is rapamycin sensitive, while TORC2 regulates the cell cytoskeleton and is rapamycin insensitive. Budding yeast TORC1 consists of either Tor1 or Tor2 in complex with Kog1, Lst8 and Tco89, while TORC2 is composed of Avo1, Avo2, Tsc11, Lst8, Bit61, Slm, Slm2 and Tor2 [[cite:PUB00078108], [cite:PUB00061649]]. In both yeast and mammals, FKBP12-rapamycin binds to Tor (Tor1, Tor2, or mTOR) in TORC1, but not to Tor (Tor2 or mTOR) in TORC2. It has been suggested that the architecture of TORC2 or its unique composition might be responsible for the observed rapamycin resistance [[cite:PUB00078109]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0044877
Molecular function Protein-containing complex binding Interacting selectively and non-covalently with a macromolecular complex.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj1g3v0052210.1
– PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1|
Domains
32
Lj1g3v0052210.2
– PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1|
Domains
32
Lj1g3v0052210.3
– PREDICTED: serine/threonine-protein kinase TOR-like isoform 1 [Glycine max] gi|356539702|ref|XP_003538334.1|
Domains
33
LotjaGi2g1v0459200.1
– Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|I1LFQ6|I1LFQ6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200
Domains
37
LotjaGi2g1v0459200.2
– Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|A0A0R0LMJ1|A0A0R0LMJ1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0459200
Domains
33

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd05169 CDD 1 20.00