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IPR037855

Source: InterPro

Description

IPR037855 is a Vacuolar protein sorting protein 36.

<p>Vps36 is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes. The GLUE domain of Vps36 allows for a tight interaction to occur between the protein and Vps28, a subunit of ESCRT-I. This interaction is critical for ubiquitinated cargo progression from early to late endosomes [[cite:PUB00039953]].</p> <p>The multivesicular body (MVB) protein-sorting pathway targets transmembrane proteins either for degradation or for function in the vacuole/lysosomes. The signal for entry into this pathway is monoubiquitination of protein cargo, which results in incorporation of cargo into luminal vesicles at late endosomes. Another crucial player is phosphatidylinositol 3-phosphate (PtdINS(3)P), which is enriched on early endosomes and on the luminal vesicles of MVBs. ESCRT (endosomal sorting complex required for transport)-I, -II and -III complexes are critical for MVB budding and sorting of monoubiquitinated cargo into the luminal vesicles [[cite:PUB00087727]]. Various Ub-binding domains (UBDs), such as UIM, UEV and NZF are found in such machineries [[cite:PUB00039953], [cite:PUB00035959]].</p> <p>The Vps 36 subunit of the ESCRT-II trafficking complex binds both phosphoinositides and ubiquitin. All members of the Vps36 family contain a divergent GRAM/PH-like domain; yeast and some other fungi have one or two NZF domains inserted in the GRAM/PH-like domain [[cite:PUB00039953], [cite:PUB00035959]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000814
Cellular component ESCRT II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.
Subterm of
Part of
GO:0032509
Biological process Endosome transport via multivesicular body sorting pathway The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.
Subterm of
GO:0043130
Molecular function Ubiquitin binding Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0303100.1
– Vacuolar protein sorting-associated protein 36; TAIR: AT5G04920.1 EAP30/Vps36 family protein; Swiss-Prot: sp|Q9FF81|VPS36_ARATH Vacuolar protein sorting-associated protein 36; TrEMBL-Plants: tr|V7AJ01|V7AJ01_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0303100
Domains
14
LotjaGi3g1v0303100.2
– Vacuolar protein sorting-associated protein 36; TAIR: AT5G04920.1 EAP30/Vps36 family protein; Swiss-Prot: sp|Q9FF81|VPS36_ARATH Vacuolar protein sorting-associated protein 36; TrEMBL-Plants: tr|V7AJ01|V7AJ01_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0303100
Domains
14
LotjaGi3g1v0303100.3
– Vacuolar protein sorting-associated protein 36; TAIR: AT5G04920.1 EAP30/Vps36 family protein; Swiss-Prot: sp|Q9FF81|VPS36_ARATH Vacuolar protein sorting-associated protein 36; TrEMBL-Plants: tr|V7AJ01|V7AJ01_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0303100
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF50729 SUPERFAMILY 1 33.33