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IPR037912 is a Microspherule protein 1.
<p>Microspherule protein 1 (MCRS1 or MSP58) is an RNA-binding protein that interacts with Daxx transcriptional regulator, relieving its repressor activity. Overexpression of MCRS1 leads to translocation of Daxx to the enlarged nucleoli in COS-1 or 293 cells [[cite:PUB00087857]]. It also interacts with fragile X messenger ribonucleoprotein 1 (FMRP), which represses specific mRNAs being transported as silent ribonucleoparticles from the cell body of a neuron to the distant synapse. MCRS1 binds to the G-quadruplex structures of the mRNA [[cite:PUB00087858]]. MCRS1 is a component of the NSL complex [[cite:PUB00060167]], the MLL1/MLL complex [[cite:PUB00063002]], and is a putative regulatory component in the chromatin remodeling INO80 complex [[cite:PUB00062156]]. The isoform MCRS2 is a cell-cycle-dependent protein which accumulates in the early S phase, and interacts with the telomerase-inhibitory protein LPTS/PinX1 [[cite:PUB00087859]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | G-quadruplex RNA binding | Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. | ||
| Cellular component | Ino80 complex | A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity. | ||
| Cellular component | MLL1 complex | A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Forkhead-associated (FHA) domain protein; TAIR: AT3G54350.1 Forkhead-associated (FHA) domain-containing protein; Swiss-Prot: sp|Q96EZ8|MCRS1_HUMAN Microspherule protein 1; TrEMBL-Plants: tr|K7KHS6|K7KHS6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0424900 | 14 | ||
| – | Microspherule protein 1; TAIR: AT3G54350.1 Forkhead-associated (FHA) domain-containing protein; Swiss-Prot: sp|Q96EZ8|MCRS1_HUMAN Microspherule protein 1; TrEMBL-Plants: tr|K7KHS6|K7KHS6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0424900 | 6 | ||
| – | Forkhead-associated (FHA) domain protein; TAIR: AT3G54350.1 Forkhead-associated (FHA) domain-containing protein; Swiss-Prot: sp|Q96EZ8|MCRS1_HUMAN Microspherule protein 1; TrEMBL-Plants: tr|V7CD65|V7CD65_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0124300 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |