Description

IPR040221 is a CDCA7/CDA7L.

<p>This entry includes CDCA7 and CDA7L.</p> <p>Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 [[cite:PUB00079135]]. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc [[cite:PUB00079136]]. This interaction affects Myc-dependent apoptosis and transformation [[cite:PUB00079138], [cite:PUB00079137], [cite:PUB00079136]]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [[cite:PUB00079139]].</p> <p>Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc [[cite:PUB00079137]]. JPO2 overexpression induces metastasis in medulloblastoma [[cite:PUB00079140]]. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [[cite:PUB00079142], [cite:PUB00079141]].</p> <p>JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter [[cite:PUB00044558]]. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways [[cite:PUB00079143]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: