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IPR040398 is a CCR4-NOT transcription complex subunit 1.
<p>Not1 is the core component of the CCR4/NOT complex, which plays roles in the negative regulation of gene expression at transcriptional and post-transcriptional levels. This entry includes Not1 (also known as Cdc39) and its homologues, such as LET-711 from Caenorhabditis elegans [[cite:PUB00099548]]. De novo variants in CNOT1 have been shown to cause neurodevelopmental delay [[cite:PUB00099656]].</p> <p>The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 [[cite:PUB00044101]]. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress [[cite:PUB00044102]]. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex [[cite:PUB00010586]]. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [[cite:PUB00044103]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. | ||
| Cellular component | CCR4-NOT core complex | The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | CCR4-NOT transcription complex subunit 1; TAIR: AT1G02080.2 transcription regulator; Swiss-Prot: sp|A1A5H6|CNOT1_DANRE CCR4-NOT transcription complex subunit 1; TrEMBL-Plants: tr|I1KJP7|I1KJP7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0050800 | 23 | ||
| – | CCR4-NOT transcription complex subunit 1; TAIR: AT1G02080.2 transcription regulator; Swiss-Prot: sp|A1A5H6|CNOT1_DANRE CCR4-NOT transcription complex subunit 1; TrEMBL-Plants: tr|I1KJP7|I1KJP7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0050800 | 23 | ||
| – | CCR4-NOT transcription complex subunit 1; TAIR: AT1G02080.2 transcription regulator; Swiss-Prot: sp|A1A5H6|CNOT1_DANRE CCR4-NOT transcription complex subunit 1; TrEMBL-Plants: tr|A0A0B2PP65|A0A0B2PP65_GLYSO CCR4-NOT transcription complex subunit 1; Found in the gene: LotjaGi3g1v0050800 | 23 | ||
| – | CCR4-NOT transcription complex subunit 1; TAIR: AT1G02080.2 transcription regulator; Swiss-Prot: sp|A1A5H6|CNOT1_DANRE CCR4-NOT transcription complex subunit 1; TrEMBL-Plants: tr|A0A0B2PP65|A0A0B2PP65_GLYSO CCR4-NOT transcription complex subunit 1; Found in the gene: LotjaGi3g1v0050800 | 23 | ||
| – | CCR4-NOT transcription complex subunit 1; TAIR: AT1G02080.2 transcription regulator; Swiss-Prot: sp|A1A5H6|CNOT1_DANRE CCR4-NOT transcription complex subunit 1; TrEMBL-Plants: tr|A0A0R0J669|A0A0R0J669_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0050800 | 23 | ||
| – | CCR4-NOT transcription complex subunit 1; TAIR: AT1G02080.2 transcription regulator; Swiss-Prot: sp|A1A5H6|CNOT1_DANRE CCR4-NOT transcription complex subunit 1; TrEMBL-Plants: tr|A0A0R0J669|A0A0R0J669_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0050800 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |