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IPR041708 is a Pseudouridine synthase PUS1/ PUS2-like.
<p>This group consists of eukaryotic pseudouridine synthases similar to Saccharomyces cerevisiae Pus1 and Pus2 [[cite:PUB00091707]]. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi) [[cite:PUB00015686]]. No cofactors are required. S. cerevisiae Pus1 catalyzes the formation of psi34 and psi36 in the intron-containing tRNAIle, psi35 in the intron-containing tRNATyr, psi27 and/or psi28 in several yeast cytoplasmic tRNAs and, psi44 in U2 small nuclear RNA (U2 snRNA) [[cite:PUB00091708]]. The presence of the intron is required for the formation of psi 34, 35 and 36. In addition S. cerevisiae PUS1 makes are psi 26, 65 and 67. C. elegans Pus1 does not modify psi44 in U2 snRNA [[cite:PUB00091709]]. Mouse Pus1 makes psi27/28 in pre- tRNASer , tRNAVal and tRNAIle, psi 34/36 in tRNAIle and, psi 32 and potentially 67 in tRNAVal. Psi44 in U2 snRNA and psi32 in tRNAs are highly phylogenetically conserved. Psi 26,27,28,34,35,36,65 and 67 in tRNAs are less highly conserved. Mouse Pus1p regulates nuclear receptor activity through pseudouridylation of Steroid Receptor RNA Activator [[cite:PUB00091710]]. Missense mutation in human PUS1 causes mitochondrial myopathy and sideroblastic anemia (MLASA) [[cite:PUB00091711]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. | ||
| Biological process | TRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | TRNA pseudouridine synthase A, related protein; TAIR: AT2G30320.1 Pseudouridine synthase family protein; Swiss-Prot: sp|O22928|PUSH_ARATH Putative tRNA pseudouridine synthase; TrEMBL-Plants: tr|K7KAB0|K7KAB0_SOYBN tRNA pseudouridine synthase; Found in the gene: LotjaGi1g1v0109500 | 13 | ||
| – | TRNA pseudouridine synthase A; TAIR: AT2G30320.1 Pseudouridine synthase family protein; Swiss-Prot: sp|O22928|PUSH_ARATH Putative tRNA pseudouridine synthase; TrEMBL-Plants: tr|K7KAA8|K7KAA8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0110600 | 19 | ||
| – | TRNA pseudouridine synthase A, related protein; TAIR: AT1G20370.1 Pseudouridine synthase family protein; Swiss-Prot: sp|Q6CC39|PUS1_YARLI tRNA pseudouridine synthase 1; TrEMBL-Plants: tr|G7JGU0|G7JGU0_MEDTR tRNA pseudouridine synthase A, related protein; Found in the gene: LotjaGi4g1v0286200 | 13 | ||
| – | TRNA pseudouridine synthase A, related protein; TAIR: AT1G20370.1 Pseudouridine synthase family protein; Swiss-Prot: sp|Q6CC39|PUS1_YARLI tRNA pseudouridine synthase 1; TrEMBL-Plants: tr|G7JGU0|G7JGU0_MEDTR tRNA pseudouridine synthase A, related protein; Found in the gene: LotjaGi4g1v0286200 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |