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IPR043205 is a Cytochrome b561/Cytochrome b reductase 1-like.
<p>This entry represents a group of transmembrane reductases, including CYBRD1/CYB561/CYB561A3 from humans.</p> <p>Cytochrome b561 is a ferric-chelate reductase that reduces Fe3+ to Fe2+ before its transport from the endosome to the cytoplasm. It probably uses ascorbate as an electron donor [[cite:PUB00069419], [cite:PUB00069420]].</p> <p>Cytochrome b reductase 1 (CYBRD1) is an iron-regulated ferric reductase that catalyses the reduction of ferric to ferrous ion in the process of iron absorption in duodenal enterocytes [[cite:PUB00069689], [cite:PUB00069678]]. It shares protein sequence similarity with cytochrome b561, an enzyme involved in the regeneration of ascorbic acid (AA) from semi dehydroascorbic acid (DHA) or ascorbate free radical (AFR) [[cite:PUB00069689]].</p> <p>CYB561A3 is a lysosomal membrane ascorbate-dependent ferrireductas.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Cytochrome B561 family protein; TAIR: AT1G14730.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q67ZF6|ACFR3_ARATH Probable transmembrane ascorbate ferrireductase 3; TrEMBL-Plants: tr|A0A151RH42|A0A151RH42_CAJCA Cytochrome b reductase 1; Found in the gene: LotjaGi2g1v0005400 | 13 | ||
– | Cytochrome B561, putative; TAIR: AT5G38630.1 cytochrome B561-1; Swiss-Prot: sp|Q9SWS1|ACFR2_ARATH Probable transmembrane ascorbate ferrireductase 2; TrEMBL-Plants: tr|A0A0R4J5Z6|A0A0R4J5Z6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0055900 | 13 | ||
– | Cytochrome b561; TAIR: AT1G26100.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q9C540|ACFR4_ARATH Probable transmembrane ascorbate ferrireductase 4; TrEMBL-Plants: tr|I3SU65|I3SU65_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0282500 | 13 | ||
– | Cytochrome B561 family protein; TAIR: AT1G14730.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q67ZF6|ACFR3_ARATH Probable transmembrane ascorbate ferrireductase 3; TrEMBL-Plants: tr|I3S4N6|I3S4N6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0357800 | 13 | ||
– | Cytochrome b561; TAIR: AT4G25570.2 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q8L856|ACFR1_ARATH Transmembrane ascorbate ferrireductase 1; TrEMBL-Plants: tr|B7FIG9|B7FIG9_MEDTR Transmembrane ascorbate ferrireductase; Found in the gene: LotjaGi5g1v0301400 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd08766 | CDD | 1 | 20.00 |