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IPR006593 is a Cytochrome b561/ferric reductase transmembrane.
<p>Cytochromes b561 constitute a class of intrinsic membrane proteins containing two haem molecules that are involved in ascorbate (vitamin C) regeneration. They have been suggested to function as electron transporters, shuttling electrons across membranes from ascorbate to an acceptor molecule. The one-electron oxidation product of ascorbate, monodehydro-ascorbate (MDHA) has been shown to function as an electon acceptor for mammalian and plant cytochromes b561. The cytochrome b561-catalysed reduction of MDHA results in the regeneration of the fully reduced ascorbate molecule. Cytochromes b561 have been identified in a large number of phylogenetically distant species, but are absent in prokaryotes. Most species contain three or four cytochrome b561 paralogous proteins [[cite:PUB00018403]].</p> <p>Members of the cytochrome b561 protein family are characterised by a number of structural features, likely to play an essential part in their function. They are highly hydrophobic proteins with six transmembrane helices (named TMH1 through TMH6), four conserved histidine residues, probably coordinating the two haem molecules, and predicted substrate-binding sites for ascorbate and MDHA [[cite:PUB00018403]]. The functionally relevant and structurally most conserved region in the cytochrome b561 family is the TMH2 to -5 4-helix core with an amino acid composition that is very well conserved in the inner surface and somewhat less conserved in the outer surface of the core. The two terminal helices (TMH1 and TMH6) are less conserved [[cite:PUB00018313], [cite:PUB00018404]].</p> <p>The entry represents a conserved region containing six transmembrane helices, found in cytochrome b651 and homologous proteins including some ferric reductases.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable transmembrane ascorbate ferrireductase 3-like [Cicer arietinum] gi|502168355|ref|XP_004514369.1| | 11 | ||
| – | PREDICTED: probable transmembrane ascorbate ferrireductase 2-like [Glycine max] gi|356573901|ref|XP_003555094.1| | 14 | ||
| – | Auxin-responsive family protein [Theobroma cacao] gi|508781646|gb|EOY28902.1| | 9 | ||
| – | Cytochrome b561/ferric reductase transmembrane with DOMON related domain [Arabidopsis thaliana] gi|15233202|ref|NP_191734.1| | 21 | ||
| – | PREDICTED: probable transmembrane ascorbate ferrireductase 4-like [Glycine max] gi|356496004|ref|XP_003516860.1| | 10 | ||
| – | Dopamine beta-monooxygenase [Medicago truncatula] gi|357494649|ref|XP_003617613.1| | 22 | ||
| – | Auxin-induced in root cultures protein [Medicago truncatula] gi|357495381|ref|XP_003617979.1| | 24 | ||
| – | Ferric-chelate reductase [Medicago truncatula] gi|358346379|ref|XP_003637246.1| | 23 | ||
| – | PREDICTED: auxin-induced in root cultures protein 12-like [Glycine max] gi|356532614|ref|XP_003534866.1| | 24 | ||
| – | Cytochrome B561-related protein [Medicago truncatula] gi|357476429|ref|XP_003608500.1| | 12 | ||
| – | Cytochrome B561-related protein [Medicago truncatula] gi|357476429|ref|XP_003608500.1| | 12 | ||
| – | Auxin-induced in root cultures protein [Medicago truncatula] gi|357504947|ref|XP_003622762.1| | 24 | ||
| – | Cytochrome b reductase [Medicago truncatula] gi|358349463|ref|XP_003638756.1| | 11 | ||
| – | DOMON domain-containing protein / dopamine beta-monooxygenase N-terminal domain-containing protein [Theobroma cacao] gi|508721534|gb|EOY13431.1| | 25 | ||
| – | PREDICTED: transmembrane ascorbate ferrireductase 1-like isoform X1 [Cicer arietinum] gi|502119311|ref|XP_004496575.1| | 11 | ||
| – | Auxin-responsive family protein [Theobroma cacao] gi|508781646|gb|EOY28902.1| | 23 | ||
| – | Cytochrome B561-related protein [Beta vulgaris] gi|99646732|emb|CAK22421.1| | 12 | ||
| – | PREDICTED: auxin-induced in root cultures protein 12-like [Glycine max] gi|356532614|ref|XP_003534866.1| | 24 | ||
| – | DOMON domain-containing protein / dopamine beta-monooxygenase N-terminal domain-containing protein [Theobroma cacao] gi|508721534|gb|EOY13431.1| | 25 | ||
| – | Cytochrome b561 and domon domain-containing protein; TAIR: AT2G04850.1 Auxin-responsive family protein; Swiss-Prot: sp|Q9SJ74|B561G_ARATH Cytochrome b561 and DOMON domain-containing protein At2g04850; TrEMBL-Plants: tr|I3S8L2|I3S8L2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0007600 | 24 | ||
| – | Cytochrome b561 and domon domain-containing protein; TAIR: AT4G12980.1 Auxin-responsive family protein; Swiss-Prot: sp|Q9SV71|B561O_ARATH Cytochrome b561 and DOMON domain-containing protein At4g12980; TrEMBL-Plants: tr|A0A151U2B5|A0A151U2B5_CAJCA Ferric-chelate reductase 1; Found in the gene: LotjaGi1g1v0026100 | 22 | ||
| – | Cytochrome b561 domain-containing protein; TAIR: AT2G30890.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|O80854|B561L_ARATH Cytochrome b561 domain-containing protein At2g30890; TrEMBL-Plants: tr|V7BJS7|V7BJS7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0043700 | 10 | ||
| – | Cytochrome b561 and DOMON domain-containing protein; TAIR: AT3G25290.1 Auxin-responsive family protein; Swiss-Prot: sp|Q9LSE7|B561C_ARATH Cytochrome b561 and DOMON domain-containing protein At3g25290; TrEMBL-Plants: tr|I1N1W5|I1N1W5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0593800 | 24 | ||
| – | Cytochrome b561 and domon domain-containing protein; TAIR: AT3G61750.1 Cytochrome b561/ferric reductase transmembrane with DOMON related domain-containing protein; Swiss-Prot: sp|Q9M363|B561I_ARATH Cytochrome b561 and DOMON domain-containing protein At3g61750; TrEMBL-Plants: tr|A0A0B2RSM9|A0A0B2RSM9_GLYSO Putative ferric-chelate reductase 1; Found in the gene: LotjaGi1g1v0792400 | 23 | ||
| – | Cytochrome B561 family protein; TAIR: AT1G14730.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q67ZF6|ACFR3_ARATH Probable transmembrane ascorbate ferrireductase 3; TrEMBL-Plants: tr|A0A151RH42|A0A151RH42_CAJCA Cytochrome b reductase 1; Found in the gene: LotjaGi2g1v0005400 | 13 | ||
| – | Cytochrome B561, putative; TAIR: AT5G38630.1 cytochrome B561-1; Swiss-Prot: sp|Q9SWS1|ACFR2_ARATH Probable transmembrane ascorbate ferrireductase 2; TrEMBL-Plants: tr|A0A0R4J5Z6|A0A0R4J5Z6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0055900 | 13 | ||
| – | Cytochrome b561; TAIR: AT1G26100.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q9C540|ACFR4_ARATH Probable transmembrane ascorbate ferrireductase 4; TrEMBL-Plants: tr|I3SU65|I3SU65_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0282500 | 13 | ||
| – | Cytochrome b561 and DOMON domain-containing protein; TAIR: AT3G07570.1 Cytochrome b561/ferric reductase transmembrane with DOMON related domain-containing protein; Swiss-Prot: sp|Q0WRW8|B561K_ARATH Cytochrome b561 and DOMON domain-containing protein At3g07570; TrEMBL-Plants: tr|V7ANQ8|V7ANQ8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0391400 | 23 | ||
| – | Cytochrome b561 and DOMON domain-containing protein; TAIR: AT5G47530.1 Auxin-responsive family protein; Swiss-Prot: sp|Q9FGK4|B561J_ARATH Cytochrome b561 and DOMON domain-containing protein At5g47530; TrEMBL-Plants: tr|A0A151SU37|A0A151SU37_CAJCA Auxin-induced in root cultures protein 12; Found in the gene: LotjaGi4g1v0008100 | 24 | ||
| – | Cytochrome b561 domain-containing protein; TAIR: AT4G18260.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q0WPS2|B561M_ARATH Cytochrome b561 domain-containing protein At4g18260; TrEMBL-Plants: tr|A0A097PHP3|A0A097PHP3_MEDTR Cytochrome B561-like protein; Found in the gene: LotjaGi4g1v0023000 | 13 | ||
| – | Cytochrome b561 domain-containing protein; TAIR: AT4G18260.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q0WPS2|B561M_ARATH Cytochrome b561 domain-containing protein At4g18260; TrEMBL-Plants: tr|V7CNV4|V7CNV4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0023000 | 13 | ||
| – | Cytochrome B561 family protein; TAIR: AT1G14730.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q67ZF6|ACFR3_ARATH Probable transmembrane ascorbate ferrireductase 3; TrEMBL-Plants: tr|I3S4N6|I3S4N6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0357800 | 13 | ||
| – | Cytochrome b561 and DOMON domain-containing protein; TAIR: AT5G54830.1 DOMON domain-containing protein / dopamine beta-monooxygenase N-terminal domain-containing protein; Swiss-Prot: sp|Q9FFU6|B561A_ARATH Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830; TrEMBL-Plants: tr|K7L6C8|K7L6C8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0391000 | 25 | ||
| – | Cytochrome b561; TAIR: AT4G25570.2 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q8L856|ACFR1_ARATH Transmembrane ascorbate ferrireductase 1; TrEMBL-Plants: tr|B7FIG9|B7FIG9_MEDTR Transmembrane ascorbate ferrireductase; Found in the gene: LotjaGi5g1v0301400 | 13 | ||
| – | Cytochrome b561 domain-containing protein; TAIR: AT4G18260.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q0WPS2|B561M_ARATH Cytochrome b561 domain-containing protein At4g18260; TrEMBL-Plants: tr|K7L9Z4|K7L9Z4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0173700 | 14 | ||
| – | Cytochrome b561 domain-containing protein; TAIR: AT4G18260.1 Cytochrome b561/ferric reductase transmembrane protein family; Swiss-Prot: sp|Q0WPS2|B561M_ARATH Cytochrome b561 domain-containing protein At4g18260; TrEMBL-Plants: tr|V7BJS7|V7BJS7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0173700 | 13 | ||
| – | Cytochrome b561 and domon domain-containing protein; TAIR: AT4G17280.1 Auxin-responsive family protein; Swiss-Prot: sp|Q8VYH6|B651B_ARATH Cytochrome b561 and DOMON domain-containing protein At4g17280; TrEMBL-Plants: tr|I1L009|I1L009_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0285900 | 24 | ||
| – | Cytochrome b561 and domon domain-containing protein; TAIR: AT5G54830.1 DOMON domain-containing protein / dopamine beta-monooxygenase N-terminal domain-containing protein; Swiss-Prot: sp|Q9FFU6|B561A_ARATH Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830; TrEMBL-Plants: tr|G7IP50|G7IP50_MEDTR Dopamine beta-monooxygenase, putative; Found in the gene: LotjaGi6g1v0311800 | 26 | ||
| – | Cytochrome b561 and domon domain-containing protein; TAIR: AT5G54830.1 DOMON domain-containing protein / dopamine beta-monooxygenase N-terminal domain-containing protein; Swiss-Prot: sp|Q9FFU6|B561A_ARATH Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830; TrEMBL-Plants: tr|G7IP50|G7IP50_MEDTR Dopamine beta-monooxygenase, putative; Found in the gene: LotjaGi6g1v0311800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd09631 | CDD | 1 | 2.56 |