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Field | Value |
---|---|
Namespace | Cellular component |
Short description | Transcription factor TFIIF complex |
Full defintion | A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. |
Subterm of |
The relationship of GO:0005674 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0005674, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | jl |
PMID | Dissection of transcription factor TFIIF functional domains required for initiation and elongation. Proc Natl Acad Sci U S A. 1995 Jun 20; 92 (13): 6042–6.PMID: 7597077 TFIIF is unique among the general transcription factors because of its ability to control the activity of RNA polymerase II at both the initiation and elongation stages of transcription. Mammalian TFIIF, a heterodimer of approximately 30-kDa (RAP30) and approximately 70-kDa (RAP74) subunits, assists TFIIB in recruiting RNA polymerase II into the preinitiation complex and activates the overall rate of RNA chain elongation by suppressing transient pausing by polymerase at many sites on DNA templates. A major objective of efforts to understand how TFIIF regulates transcription has been to establish the relationship between its initiation and elongation activities. Here we establish this relationship by demonstrating that TFIIF transcriptional activities are mediated by separable functional domains. To accomplish this, we sought and identified distinct classes of RAP30 mutations that selectively block TFIIF activity in transcription initiation and elongation. We propose that (i) TFIIF initiation activity is mediated at least in part by RAP30 C-terminal sequences that include a cryptic DNA-binding domain similar to conserved region 4 of bacterial sigma factors and (ii) TFIIF elongation activity is mediated in part by RAP30 sequences located immediately upstream of the C terminus in a region proposed to bind RNA polymerase II and by additional sequences located in the RAP30 N terminus. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
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– | PREDICTED: general transcription factor IIF subunit 2-like [Glycine max] gi|356511855|ref|XP_003524637.1| | 3 | ||
– | PREDICTED: transcription initiation factor IIF subunit beta-like [Glycine max] gi|356518378|ref|XP_003527856.1| | 3 | ||
– | PREDICTED: transcription initiation factor IIF subunit beta-like [Glycine max] gi|356518378|ref|XP_003527856.1| | 3 | ||
– | Transcription initiation factor IIF subunit beta; TAIR: AT1G75510.1 Transcription initiation factor IIF, beta subunit; Swiss-Prot: sp|O94424|T2FB_SCHPO Transcription initiation factor IIF subunit beta; TrEMBL-Plants: tr|I3T827|I3T827_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0424300 | 3 | ||
– | Transcription initiation factor IIF subunit beta; TAIR: AT1G75510.1 Transcription initiation factor IIF, beta subunit; Swiss-Prot: sp|O94424|T2FB_SCHPO Transcription initiation factor IIF subunit beta; TrEMBL-Plants: tr|I3T827|I3T827_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0424300 | 3 | ||
– | Transcription initiation factor IIF subunit beta, putative; TAIR: AT3G52270.1 Transcription initiation factor IIF, beta subunit; Swiss-Prot: sp|Q2T9L9|T2FB_BOVIN General transcription factor IIF subunit 2; TrEMBL-Plants: tr|K7KP46|K7KP46_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0102000 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Transcription initiation from RNA polymerase II promoter | 1 | 16.67 |