Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR000399

Source: InterPro

Description

IPR000399 is a TPP-binding enzyme, conserved site.

<p>A number of enzymes require thiamine pyrophosphate (TPP) (vitamin B1) as a cofactor. It has been shown [[cite:PUB00015103]] that some of these enzymes are structurally related.</p> <p>Enzymes with a TPP-binding domain include:</p> <ul> <li>Pyruvate oxidase (POX) ([ec:1.2.3.3]). Reaction catalysed: pyruvate + orthophosphate + O(2) + H(2)O = acetyl phosphate + CO(2) + H(2)O(2).</li> <li>Pyruvate decarboxylase (PDC) ([ec:4.1.1.1]) [[cite:PUB00015103]]. Reaction catalysed: pyruvate = acetaldehyde + CO(2).</li> <li>Indolepyruvate decarboxylase ([ec:4.1.1.74]) [[cite:PUB00016247]]. Reaction catalysed: indole-3-pyruvate = indole-3-acetaldehyde + CO(2).</li> <li>Acetolactate synthase (ALS) ([ec:4.1.3.18]). Reaction catalysed: 2x pyruvate = acetolactate + CO(2).</li> <li>Benzoylformate decarboxylase (BFD) ([ec:4.1.1.7]) [[cite:PUB00016248]]. Reaction catalysed: benzoylformate = benzaldehyde + CO(2).</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000287
Molecular function Magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
Subterm of
GO:0030976
Molecular function Thiamine pyrophosphate binding Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj1g3v1513620.1
– Acetolactate synthase [Medicago littoralis] gi|164453114|gb|ABY57316.1|
Domains
20
Lj2g3v0919440.1
– PREDICTED: 2-hydroxyacyl-CoA lyase-like [Glycine max] gi|356553206|ref|XP_003544949.1|
Domains
19
Lj6g3v2043240.1
– PREDICTED: acetolactate synthase 1, chloroplastic-like [Cicer arietinum] gi|502077817|ref|XP_004485753.1|
Domains
20
LotjaGi1g1v0338500.1
– Acetolactate synthase; TAIR: AT3G48560.1 chlorsulfuron/imidazolinone resistant 1; Swiss-Prot: sp|P09114|ILVB2_TOBAC Acetolactate synthase 2, chloroplastic; TrEMBL-Plants: tr|B0FBK4|B0FBK4_9FABA Acetolactate synthase; Found in the gene: LotjaGi1g1v0338500
Domains
21
LotjaGi2g1v0238100.1
– Acetolactate synthase; TAIR: AT5G17380.1 Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Swiss-Prot: sp|Q9LF46|HACL_ARATH 2-hydroxyacyl-CoA lyase; TrEMBL-Plants: tr|A0A151TX24|A0A151TX24_CAJCA 2-hydroxyacyl-CoA lyase 1; Found in the gene: LotjaGi2g1v0238100
Domains
19
LotjaGi6g1v0333700.1
– Acetolactate synthase; TAIR: AT3G48560.1 chlorsulfuron/imidazolinone resistant 1; Swiss-Prot: sp|P09114|ILVB2_TOBAC Acetolactate synthase 2, chloroplastic; TrEMBL-Plants: tr|D2DJQ3|D2DJQ3_SOYBN Acetolactate synthase; Found in the gene: LotjaGi6g1v0333700
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07035 CDD 1 16.67