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IPR012001 is a Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain.
<p>A number of enzymes require thiamine pyrophosphate (TPP) (vitamin B1) as a cofactor. It has been shown [[cite:PUB00015103]] that some of these enzymes are structurally related. There are two different functional modules in the thiamin diphosphate-binding fold, the pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules. This represents the N-terminal TPP-binding domain that in some members has been described as the Pyr-binding module.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Thiamine pyrophosphate binding | Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Thiamine pyrophosphate dependent pyruvate decarboxylase family protein [Theobroma cacao] gi|508715239|gb|EOY07136.1| | 19 | ||
| – | PREDICTED: protein PHYLLO, chloroplastic-like [Cicer arietinum] gi|502154072|ref|XP_004509573.1| | 19 | ||
| – | PREDICTED: protein PHYLLO, chloroplastic-like [Glycine max] gi|356555334|ref|XP_003545988.1| | 15 | ||
| – | Acetolactate synthase [Medicago littoralis] gi|164453114|gb|ABY57316.1| | 20 | ||
| – | Pyruvate decarboxylase 1 [Lotus corniculatus] gi|29373077|gb|AAO72533.1| | 18 | ||
| – | PREDICTED: 2-hydroxyacyl-CoA lyase-like [Glycine max] gi|356553206|ref|XP_003544949.1| | 19 | ||
| – | Pyruvate decarboxylase isozyme 1 [Lotus japonicus] gi|51587336|emb|CAG30578.1| | 18 | ||
| – | 18 | |||
| – | PREDICTED: acetolactate synthase 1, chloroplastic-like [Cicer arietinum] gi|502077817|ref|XP_004485753.1| | 20 | ||
| – | 13 | |||
| – | Acetolactate synthase; TAIR: AT3G48560.1 chlorsulfuron/imidazolinone resistant 1; Swiss-Prot: sp|P09114|ILVB2_TOBAC Acetolactate synthase 2, chloroplastic; TrEMBL-Plants: tr|B0FBK4|B0FBK4_9FABA Acetolactate synthase; Found in the gene: LotjaGi1g1v0338500 | 21 | ||
| – | Pyruvate decarboxylase; TAIR: AT4G33070.1 Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Swiss-Prot: sp|O82647|PDC1_ARATH Pyruvate decarboxylase 1; TrEMBL-Plants: tr|Q84V95|Q84V95_LOTCO Pyruvate decarboxylase 1; Found in the gene: LotjaGi1g1v0443800 | 18 | ||
| – | Pyruvate decarboxylase; TAIR: AT4G33070.1 Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Swiss-Prot: sp|O82647|PDC1_ARATH Pyruvate decarboxylase 1; TrEMBL-Plants: tr|Q84V95|Q84V95_LOTCO Pyruvate decarboxylase 1; Found in the gene: LotjaGi1g1v0443800 | 18 | ||
| – | Acetolactate synthase; TAIR: AT5G17380.1 Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Swiss-Prot: sp|Q9LF46|HACL_ARATH 2-hydroxyacyl-CoA lyase; TrEMBL-Plants: tr|A0A151TX24|A0A151TX24_CAJCA 2-hydroxyacyl-CoA lyase 1; Found in the gene: LotjaGi2g1v0238100 | 19 | ||
| – | Pyruvate decarboxylase; TAIR: AT5G54960.1 pyruvate decarboxylase-2; Swiss-Prot: sp|Q9FFT4|PDC2_ARATH Pyruvate decarboxylase 2; TrEMBL-Plants: tr|A0A061EQM3|A0A061EQM3_THECC Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Found in the gene: LotjaGi3g1v0195000 | 19 | ||
| – | Pyruvate decarboxylase; TAIR: AT5G54960.1 pyruvate decarboxylase-2; Swiss-Prot: sp|Q9FFT4|PDC2_ARATH Pyruvate decarboxylase 2; TrEMBL-Plants: tr|A0A061EQM3|A0A061EQM3_THECC Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Found in the gene: LotjaGi3g1v0195000 | 19 | ||
| – | Pyruvate decarboxylase; TAIR: AT5G54960.1 pyruvate decarboxylase-2; Swiss-Prot: sp|Q9FFT4|PDC2_ARATH Pyruvate decarboxylase 2; TrEMBL-Plants: tr|A0A061EQM3|A0A061EQM3_THECC Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Found in the gene: LotjaGi3g1v0195000 | 19 | ||
| – | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; TAIR: AT1G68890.1 2-oxoglutarate decarboxylase/hydro-lyase/magnesium ion-binding protein; Swiss-Prot: sp|Q15KI9|PHYLO_ARATH Protein PHYLLO, chloroplastic; TrEMBL-Plants: tr|K7MEA2|K7MEA2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0153600 | 38 | ||
| – | Acetolactate synthase; TAIR: AT5G17380.1 Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Swiss-Prot: sp|Q9LF46|HACL_ARATH 2-hydroxyacyl-CoA lyase; TrEMBL-Plants: tr|A0A151TX24|A0A151TX24_CAJCA 2-hydroxyacyl-CoA lyase 1; Found in the gene: LotjaGi4g1v0332100_LC | 8 | ||
| – | Acetolactate synthase; TAIR: AT5G17380.1 Thiamine pyrophosphate dependent pyruvate decarboxylase family protein; Swiss-Prot: sp|Q9LF46|HACL_ARATH 2-hydroxyacyl-CoA lyase; TrEMBL-Plants: tr|A0A151TX24|A0A151TX24_CAJCA 2-hydroxyacyl-CoA lyase 1; Found in the gene: LotjaGi4g1v0332100_LC | 8 | ||
| – | Pyruvate decarboxylase; TAIR: AT5G54960.1 pyruvate decarboxylase-2; Swiss-Prot: sp|P51850|PDC1_PEA Pyruvate decarboxylase 1; TrEMBL-Plants: tr|Q684K0|Q684K0_LOTJA Pyruvate decarboxylase isozyme 1; Found in the gene: LotjaGi6g1v0324800 | 18 | ||
| – | Acetolactate synthase; TAIR: AT3G48560.1 chlorsulfuron/imidazolinone resistant 1; Swiss-Prot: sp|P09114|ILVB2_TOBAC Acetolactate synthase 2, chloroplastic; TrEMBL-Plants: tr|D2DJQ3|D2DJQ3_SOYBN Acetolactate synthase; Found in the gene: LotjaGi6g1v0333700 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07035 | CDD | 1 | 4.55 |