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IPR000783 is a RNA polymerase, subunit H/Rpb5 C-terminal.
<p>Prokaryotes contain a single DNA-dependent RNA polymerase (RNAP; [ec:2.7.7.6]) that is responsible for the transcription of all genes, while eukaryotes have three classes of RNAPs (I-III) that transcribe different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. Certain subunits of RNAPs, including RPB5 (POLR2E in mammals), are common to all three eukaryotic polymerases. RPB5 plays a role in the transcription activation process. Eukaryotic RPB5 has a bipartite structure consisting of a unique N-terminal region ([interpro:IPR005571]), plus a C-terminal region that is structurally homologous to the prokaryotic RPB5 homologue, subunit H (gene rpoH) [[cite:PUB00008456], [cite:PUB00003393], [cite:PUB00004780], [cite:PUB00008455]].</p> <p>This entry represents prokaryotic subunit H and the C-terminal domain of eukaryotic RPB5, which share a two-layer α/β fold, with a core structure of β/α/β/α/β(2).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. | ||
| Biological process | Transcription, DNA-templated | The cellular synthesis of RNA on a template of DNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA polymerase subunit, RPB5; RNA polymerase Rpb5, N-terminal [Medicago truncatula] gi|87162511|gb|ABD28306.1| | 13 | ||
| – | PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC1-like [Cicer arietinum] gi|502108221|ref|XP_004493418.1| | 14 | ||
| – | PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC1-like [Cicer arietinum] gi|502158924|ref|XP_004511328.1| | 12 | ||
| – | PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC1-like [Cicer arietinum] gi|502158924|ref|XP_004511328.1| | 14 | ||
| – | PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC1-like [Cicer arietinum] gi|502160738|ref|XP_004511874.1| | 12 | ||
| – | DNA-directed RNA polymerase II; TAIR: AT3G57080.1 Eukaryotic rpb5 RNA polymerase subunit family protein; Swiss-Prot: sp|Q9M1J2|RPE5A_ARATH DNA-directed RNA polymerase V subunit 5A; TrEMBL-Plants: tr|V7CXU1|V7CXU1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0665900 | 16 | ||
| – | DNA-directed RNA polymerase II; TAIR: AT3G22320.1 Eukaryotic rpb5 RNA polymerase subunit family protein; Swiss-Prot: sp|O81098|RPB5A_ARATH DNA-directed RNA polymerases II and IV subunit 5A; TrEMBL-Plants: tr|I3SCP2|I3SCP2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0219500 | 17 | ||
| – | DNA-directed RNA polymerase II, putative; TAIR: AT3G54490.1 RNA polymerase II fifth largest subunit, E; Swiss-Prot: sp|Q9M1H8|RPE5C_ARATH DNA-directed RNA polymerase V subunit 5C; TrEMBL-Plants: tr|Q2HW77|Q2HW77_MEDTR RNA polymerase subunit, RPB5; RNA polymerase Rpb5, N-terminal; Found in the gene: LotjaGi3g1v0112400 | 15 | ||
| – | DNA-directed RNA polymerase II; TAIR: AT3G22320.1 Eukaryotic rpb5 RNA polymerase subunit family protein; Swiss-Prot: sp|O81098|RPB5A_ARATH DNA-directed RNA polymerases II and IV subunit 5A; TrEMBL-Plants: tr|C6SVA4|C6SVA4_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0457100 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF55287 | SUPERFAMILY | 1 | 11.11 |