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IPR001161 is a Helicase XPB/Ssl2.
<p>XPB/Ssl2 helicase (also known as Ercc3/RepB/XPB/Rad25/Ssl2/haywire) is a core subunit of the eukaryotic basal transcription factor complex TFIIH which plays a dual role in transcription and DNA repair [[cite:PUB00076972]]. It is involved in nucleotide excision repair (NER) of DNA and in RNA transcription by RNA polymerase II [[cite:PUB00062805]]. The TFIIH multiprotein complex consists of a 7-subunit core (XPB, p62, p52, p44, p34, and TTDA) that is associated with a 3-subunit CDK-activating kinase module (MAT1, cyclin H and Cdk7) [[cite:PUB00062813]]. It acts by opening DNA either around the RNA transcription start site or the DNA damage [[cite:PUB00057247]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA helicase activity | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. | ||
| Biological process | Nucleotide-excision repair | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). | ||
| Biological process | Transcription initiation from RNA polymerase II promoter | Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA repair helicase XPB1-like [Cicer arietinum] gi|502139224|ref|XP_004503689.1| | 22 | ||
| – | PREDICTED: DNA repair helicase XPB1-like [Glycine max] gi|356513365|ref|XP_003525384.1| | 23 | ||
| – | DNA repair helicase; TAIR: AT5G41370.1 DNA repair helicase XPB1-like protein; Swiss-Prot: sp|Q38861|XPB1_ARATH DNA repair helicase XPB1; TrEMBL-Plants: tr|V7CS33|V7CS33_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0428600 | 23 | ||
| – | DNA repair helicase; TAIR: AT5G41370.1 DNA repair helicase XPB1-like protein; Swiss-Prot: sp|Q38861|XPB1_ARATH DNA repair helicase XPB1; TrEMBL-Plants: tr|V7CS33|V7CS33_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0428600 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |