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IPR001925

Source: InterPro

Description

IPR001925 is a Porin, eukaryotic type.

<p>Eukaryotic mitochondrial porins are voltage-dependent anion-selective channels (VDAC) that behave as general diffusion pores for small hydrophilic molecules [[cite:PUB00000661], [cite:PUB00005391], [cite:PUB00001485], [cite:PUB00002365]]. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.</p> <p>The proteins are composed of between 12 to 16 β-strands that span the mitochondrial outer membrane. Yeast contains two members of this family (genes POR1 and POR2); vertebrates have at least three members (genes VDAC1, VDAC2 and VDAC3) [[cite:PUB00001974], [cite:PUB00072140]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005741
Cellular component Mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
Subterm of
GO:0008308
Molecular function Voltage-gated anion channel activity Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
Subterm of
GO:0098656
Biological process Anion transmembrane transport The process in which an anion is transported across a membrane.
Subterm of

Associated Lotus transcripts 13

Transcript Name Description Predicted domains Domain count
Lj0g3v0086299.1
– VDAC1.3 [Lotus japonicus] gi|36957198|gb|AAQ87021.1|
Domains
9
Lj0g3v0086309.1
– VDAC1.3 [Lotus japonicus] gi|36957198|gb|AAQ87021.1|
Domains
9
Lj1g3v2942100.1
– VDAC1.1 [Lotus japonicus] gi|36957170|gb|AAQ87019.1|
Domains
9
Lj1g3v2942110.1
–
Domains
9
Lj2g3v1034580.1
– VDAC1.2 [Lotus japonicus] gi|36957183|gb|AAQ87020.1|
Domains
9
Lj2g3v1034590.1
–
Domains
9
LotjaGi1g1v0498100.1
– Mitochondrial outer membrane protein porin; TAIR: AT3G01280.1 voltage dependent anion channel 1; Swiss-Prot: sp|P42054|VDAC_PEA Outer plastidial membrane protein porin; TrEMBL-Plants: tr|Q6W2J5|Q6W2J5_LOTJA VDAC1.1; Found in the gene: LotjaGi1g1v0498100
Domains
9
LotjaGi2g1v0256500.1
– Mitochondrial outer membrane protein porin; TAIR: AT3G01280.1 voltage dependent anion channel 1; Swiss-Prot: sp|P42054|VDAC_PEA Outer plastidial membrane protein porin; TrEMBL-Plants: tr|Q6W2J4|Q6W2J4_LOTJA VDAC1.2; Found in the gene: LotjaGi2g1v0256500
Domains
9
LotjaGi2g1v0409200.1
– Outer mitochondrial membrane protein porin; TAIR: AT5G67500.3 voltage dependent anion channel 2; Swiss-Prot: sp|Q9FJX3|VDAC2_ARATH Mitochondrial outer membrane protein porin 2; TrEMBL-Plants: tr|Q6W2J2|Q6W2J2_LOTJA VDAC2.1; Found in the gene: LotjaGi2g1v0409200
Domains
8
LotjaGi4g1v0185600.1
– Mitochondrial outer membrane protein porin; TAIR: AT3G01280.1 voltage dependent anion channel 1; Swiss-Prot: sp|P42056|VDAC2_SOLTU Mitochondrial outer membrane protein porin of 36 kDa; TrEMBL-Plants: tr|Q6W2J3|Q6W2J3_LOTJA VDAC1.3; Found in the gene: LotjaGi4g1v0185600
Domains
9
LotjaGi4g1v0246600.1
– Mitochondrial outer membrane protein porin; TAIR: AT3G01280.1 voltage dependent anion channel 1; Swiss-Prot: sp|Q9SRH5|VDAC1_ARATH Mitochondrial outer membrane protein porin 1; TrEMBL-Plants: tr|A0A0L9TRN9|A0A0L9TRN9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0246600
Domains
7
LotjaGi4g1v0299800.1
– Outer mitochondrial membrane protein porin; TAIR: AT5G57490.1 voltage dependent anion channel 4; Swiss-Prot: sp|Q10S27|VDAC6_ORYSJ Mitochondrial outer membrane protein porin 6; TrEMBL-Plants: tr|Q6W2J1|Q6W2J1_LOTJA VDAC3.1; Found in the gene: LotjaGi4g1v0299800
Domains
8
LotjaGi5g1v0033000.1
– Outer mitochondrial membrane protein porin; TAIR: AT5G67500.3 voltage dependent anion channel 2; Swiss-Prot: sp|Q9FJX3|VDAC2_ARATH Mitochondrial outer membrane protein porin 2; TrEMBL-Plants: tr|I3SIM2|I3SIM2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0033000
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07306 CDD 1 7.69