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IPR002652 is a Importin-alpha, importin-beta-binding domain.
<p>This entry represents the N-terminal IBB domain of importin-alpha that contains the auto-regulatory region.</p> <p>The exchange of macromolecules between the nucleus and cytoplasm takes place through nuclear pore complexes within the nuclear membrane. Active transport of large molecules through these pore complexes require carrier proteins, called karyopherins (importins and exportins), which shuttle between the two compartments.</p> <p>Members of the importin-alpha (karyopherin-alpha) family can form heterodimers with importin-beta. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Proteins can contain one (monopartite) or two (bipartite) NLS motifs. Importin-alpha contains several armadillo (ARM) repeats, which produce a curving structure with two NLS-binding sites, a major one close to the N terminus and a minor one close to the C terminus.</p> <p>Ran GTPase helps to control the unidirectional transfer of cargo. The cytoplasm contains primarily RanGDP and the nucleus RanGTP through the actions of RanGAP and RanGEF, respectively. In the nucleus, RanGTP binds to importin-beta within the importin/cargo complex, causing a conformational change in importin-beta that releases it from importin-alpha-bound cargo. The N-terminal importin-beta-binding (IBB) domain of importin-alpha contains an auto-regulatory region that mimics the NLS motif [[cite:PUB00004894]]. The release of importin-beta frees the auto-regulatory region on importin-alpha to loop back and bind to the major NLS-binding site, causing the cargo to be released [[cite:PUB00034676]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. | ||
| Molecular function | Nuclear import signal receptor activity | Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: importin subunit alpha-1-like [Glycine max] gi|356521809|ref|XP_003529543.1| | 15 | ||
| – | PREDICTED: importin subunit alpha-1b-like isoform X1 [Cicer arietinum] gi|502117024|ref|XP_004495674.1| | 19 | ||
| – | PREDICTED: importin subunit alpha-1-like [Glycine max] gi|356556046|ref|XP_003546338.1| | 19 | ||
| – | Importin subunit alpha; TAIR: AT4G16143.1 importin alpha isoform 2; Swiss-Prot: sp|F4JL11|IMPA2_ARATH Importin subunit alpha-2; TrEMBL-Plants: tr|I1L0U6|I1L0U6_SOYBN Importin subunit alpha; Found in the gene: LotjaGi4g1v0336300 | 20 | ||
| – | Importin subunit alpha; TAIR: AT4G16143.1 importin alpha isoform 2; Swiss-Prot: sp|F4JL11|IMPA2_ARATH Importin subunit alpha-2; TrEMBL-Plants: tr|I1L0U6|I1L0U6_SOYBN Importin subunit alpha; Found in the gene: LotjaGi4g1v0336300 | 20 | ||
| – | Importin subunit alpha; TAIR: AT3G06720.1 importin alpha isoform 1; Swiss-Prot: sp|Q96321|IMPA1_ARATH Importin subunit alpha-1; TrEMBL-Plants: tr|G7I9F7|G7I9F7_MEDTR Importin subunit alpha; Found in the gene: LotjaGi5g1v0228400 | 19 | ||
| – | Importin subunit alpha; TAIR: AT3G06720.1 importin alpha isoform 1; Swiss-Prot: sp|Q71VM4|IMA1A_ORYSJ Importin subunit alpha-1a; TrEMBL-Plants: tr|G7I9F7|G7I9F7_MEDTR Importin subunit alpha; Found in the gene: LotjaGi5g1v0228400 | 15 | ||
| – | Importin subunit alpha; TAIR: AT3G06720.1 importin alpha isoform 1; Swiss-Prot: sp|Q96321|IMPA1_ARATH Importin subunit alpha-1; TrEMBL-Plants: tr|G7I9F7|G7I9F7_MEDTR Importin subunit alpha; Found in the gene: LotjaGi5g1v0228400 | 19 | ||
| – | Importin subunit alpha; TAIR: AT3G06720.1 importin alpha isoform 1; Swiss-Prot: sp|Q71VM4|IMA1A_ORYSJ Importin subunit alpha-1a; TrEMBL-Plants: tr|G7I9F7|G7I9F7_MEDTR Importin subunit alpha; Found in the gene: LotjaGi5g1v0228400 | 15 | ||
| – | Importin subunit alpha; TAIR: AT3G06720.1 importin alpha isoform 1; Swiss-Prot: sp|Q96321|IMPA1_ARATH Importin subunit alpha-1; TrEMBL-Plants: tr|I1MGI7|I1MGI7_SOYBN Importin subunit alpha; Found in the gene: LotjaGi6g1v0255500 | 19 | ||
| – | Importin subunit alpha; TAIR: AT3G06720.1 importin alpha isoform 1; Swiss-Prot: sp|Q96321|IMPA1_ARATH Importin subunit alpha-1; TrEMBL-Plants: tr|I1MGI7|I1MGI7_SOYBN Importin subunit alpha; Found in the gene: LotjaGi6g1v0255500 | 19 | ||
| – | Importin subunit alpha; TAIR: AT3G06720.1 importin alpha isoform 1; Swiss-Prot: sp|Q96321|IMPA1_ARATH Importin subunit alpha-1; TrEMBL-Plants: tr|I1MGI7|I1MGI7_SOYBN Importin subunit alpha; Found in the gene: LotjaGi6g1v0255500 | 19 | ||
| – | Importin subunit alpha; TAIR: AT4G16143.1 importin alpha isoform 2; Swiss-Prot: sp|Q71VM4|IMA1A_ORYSJ Importin subunit alpha-1a; TrEMBL-Plants: tr|I1MGI7|I1MGI7_SOYBN Importin subunit alpha; Found in the gene: LotjaGi6g1v0255500 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48371 | SUPERFAMILY | 1 | 7.69 |